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dc.creatorAleksić, Mara M.
dc.creatorKapetanović, Vera
dc.date.accessioned2024-01-17T16:09:14Z
dc.date.available2024-01-17T16:09:14Z
dc.date.issued2006
dc.identifier.issn0022-0728
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/5468
dc.description.abstractAbstract The voltammetric behavior of cefotaxime (CFX) is investigated by cyclic and square-wave voltammetry in BR buffers (pH 1.80–12.0). Based on the cathodic reduction peak at approximately 0.5 V in BR buffer (pH 2.8 and 9.25), a robust, highly reliable square-wave voltammetric method (SW) was developed for determination of CFX. The linearity was achieved by SW voltammetry in 7.5 · 109 M (3.52 ng ml1 ) to 1.0 · 107 M (47 ng ml1 ) and from 1.2 · 107 M (56.4 ng ml1 ) to 1.2 · 106 M (568.8 ng ml1 ) range at pH 2.8 with detection and quantification limits of 0.813 ng ml1 and 2.71 ng ml1 , and 12.6 ng ml1 and 42.2 ng ml1 , respectively. At pH 9.25 linear range was obtained from 4 · 108 M (18.8 ng ml1 ) to 1.6 · 107 M (75.2 ng ml1 ) with detection and quantification limits of 2.947 ng ml1 and 9.82 ng ml1 . The method was applied for CFX determination in spiked humane urine sample. A detection and quantification limits of 7.2 ng ml1 and 23.9 ng ml1 were achieved for determination of CFX in urine at pH 2.8 and 13.6 ng ml1 and 45.1 ng ml1 at pH 9.25. The comparative reference method was DPV. The proposed method was checked for determination of CFX in real human urine, and selectivity of the method over the metabolites was found to be quite satisfactory.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceJournal of Electroanalytical Chemistrysr
dc.subjectCefotaximesr
dc.subjectSquare-wave voltammetrysr
dc.subjectUrinesr
dc.titleVoltammetric behavior and square-wave voltammetric determination of cefotaxime in urinesr
dc.typearticlesr
dc.rights.licenseARRsr
dc.citation.volume593
dc.citation.issue1-2
dc.citation.spage258
dc.citation.epage266
dc.citation.rankM21
dc.identifier.wos000239295900031
dc.identifier.doi10.1016/j.jelechem.2006.06.011
dc.identifier.scopus2-s2.0-33745856584
dc.type.versionpublishedVersionsr


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