A method has been established for separation of nisoldipine and impurities, for example reactants, products of side-reactions, and photodegradation products, by HPTLC on LiChrospher Si 60 F-254s plates with detection at 280 nm. The mobile phase, cyclohexane-ethyl acetate-toluene, 7.5:7.5:10 (v/v), enables acceptable resolution of nisoldipine, in large excess, and possible impurities. Regression coefficients (r greater than or equal to 0.997), recovery (98-108%), and determination limit (0.02-0.2%) were validated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of nisoldipine in its raw material and dosage forms.
Keywords:
thin-layer chromatography / nisoldipine and impurities / pharmaceutical preparations
TY - JOUR
AU - Agbaba, Danica
AU - Vučićević, Katarina
AU - Marinković, Valentina
PY - 2004
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/546
AB - A method has been established for separation of nisoldipine and impurities, for example reactants, products of side-reactions, and photodegradation products, by HPTLC on LiChrospher Si 60 F-254s plates with detection at 280 nm. The mobile phase, cyclohexane-ethyl acetate-toluene, 7.5:7.5:10 (v/v), enables acceptable resolution of nisoldipine, in large excess, and possible impurities. Regression coefficients (r greater than or equal to 0.997), recovery (98-108%), and determination limit (0.02-0.2%) were validated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of nisoldipine in its raw material and dosage forms.
PB - Springer Heidelberg, Heidelberg
T2 - Chromatographia
T1 - Determination of nisoldipine and its impurities in pharmaceuticals
VL - 60
IS - 3-4
SP - 223
EP - 227
DO - 10.1365/s10337-004-0335-4
UR - conv_1562
ER -
@article{
author = "Agbaba, Danica and Vučićević, Katarina and Marinković, Valentina",
year = "2004",
abstract = "A method has been established for separation of nisoldipine and impurities, for example reactants, products of side-reactions, and photodegradation products, by HPTLC on LiChrospher Si 60 F-254s plates with detection at 280 nm. The mobile phase, cyclohexane-ethyl acetate-toluene, 7.5:7.5:10 (v/v), enables acceptable resolution of nisoldipine, in large excess, and possible impurities. Regression coefficients (r greater than or equal to 0.997), recovery (98-108%), and determination limit (0.02-0.2%) were validated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of nisoldipine in its raw material and dosage forms.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "Determination of nisoldipine and its impurities in pharmaceuticals",
volume = "60",
number = "3-4",
pages = "223-227",
doi = "10.1365/s10337-004-0335-4",
url = "conv_1562"
}
Agbaba, D., Vučićević, K.,& Marinković, V.. (2004). Determination of nisoldipine and its impurities in pharmaceuticals. in Chromatographia
Springer Heidelberg, Heidelberg., 60(3-4), 223-227.
https://doi.org/10.1365/s10337-004-0335-4
conv_1562
Agbaba D, Vučićević K, Marinković V. Determination of nisoldipine and its impurities in pharmaceuticals. in Chromatographia. 2004;60(3-4):223-227.
doi:10.1365/s10337-004-0335-4
conv_1562 .
Agbaba, Danica, Vučićević, Katarina, Marinković, Valentina, "Determination of nisoldipine and its impurities in pharmaceuticals" in Chromatographia, 60, no. 3-4 (2004):223-227,
https://doi.org/10.1365/s10337-004-0335-4 .,
conv_1562 .
