The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity.
Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora.
TY - JOUR
AU - Popović, Gordana
AU - Čakar, Mira
PY - 2004
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/550
AB - The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity.
AB - Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora.
PB - Srpsko hemijsko društvo, Beograd
T2 - Journal of the Serbian Chemical Society
T1 - The effect of β-cyclodextrin and pH on bifonazole hydrosolubility
T1 - Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi
VL - 69
IS - 3
SP - 225
EP - 231
DO - 10.2298/JSC0403225P
ER -
@article{
author = "Popović, Gordana and Čakar, Mira",
year = "2004",
abstract = "The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity., Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "The effect of β-cyclodextrin and pH on bifonazole hydrosolubility, Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi",
volume = "69",
number = "3",
pages = "225-231",
doi = "10.2298/JSC0403225P"
}
Popović, G.,& Čakar, M.. (2004). The effect of β-cyclodextrin and pH on bifonazole hydrosolubility. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 69(3), 225-231.
https://doi.org/10.2298/JSC0403225P
Popović G, Čakar M. The effect of β-cyclodextrin and pH on bifonazole hydrosolubility. in Journal of the Serbian Chemical Society. 2004;69(3):225-231.
doi:10.2298/JSC0403225P .
Popović, Gordana, Čakar, Mira, "The effect of β-cyclodextrin and pH on bifonazole hydrosolubility" in Journal of the Serbian Chemical Society, 69, no. 3 (2004):225-231,
https://doi.org/10.2298/JSC0403225P . .
