The effect of β-cyclodextrin and pH on bifonazole hydrosolubility
Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi
Abstract
The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity.
Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora.
Keywords:
bifonazole / acidity constant / solubility / β-cyclodextrin / beta-cyclodextrinSource:
Journal of the Serbian Chemical Society, 2004, 69, 3, 225-231Publisher:
- Srpsko hemijsko društvo, Beograd
Note:
- Ministarstvo nauke RS, br. 1458
DOI: 10.2298/JSC0403225P
ISSN: 0352-5139
WoS: 000220461000006
Scopus: 2-s2.0-2142702393
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PharmacyTY - JOUR AU - Popović, Gordana AU - Čakar, Mira PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/550 AB - The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity. AB - Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - The effect of β-cyclodextrin and pH on bifonazole hydrosolubility T1 - Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi VL - 69 IS - 3 SP - 225 EP - 231 DO - 10.2298/JSC0403225P ER -
@article{ author = "Popović, Gordana and Čakar, Mira", year = "2004", abstract = "The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity., Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "The effect of β-cyclodextrin and pH on bifonazole hydrosolubility, Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi", volume = "69", number = "3", pages = "225-231", doi = "10.2298/JSC0403225P" }
Popović, G.,& Čakar, M.. (2004). The effect of β-cyclodextrin and pH on bifonazole hydrosolubility. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 69(3), 225-231. https://doi.org/10.2298/JSC0403225P
Popović G, Čakar M. The effect of β-cyclodextrin and pH on bifonazole hydrosolubility. in Journal of the Serbian Chemical Society. 2004;69(3):225-231. doi:10.2298/JSC0403225P .
Popović, Gordana, Čakar, Mira, "The effect of β-cyclodextrin and pH on bifonazole hydrosolubility" in Journal of the Serbian Chemical Society, 69, no. 3 (2004):225-231, https://doi.org/10.2298/JSC0403225P . .