Приказ основних података о документу
The effect of β-cyclodextrin and pH on bifonazole hydrosolubility
Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi
dc.creator | Popović, Gordana | |
dc.creator | Čakar, Mira | |
dc.date.accessioned | 2019-09-02T10:59:54Z | |
dc.date.available | 2019-09-02T10:59:54Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/550 | |
dc.description.abstract | The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S=10-5.79+10-(pH + 0.07))were calculated. The influence of β-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 β-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 β-cyclodextrin respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of β-cyclodextrin and that in water decreased in parallel to the increase of acidity. | en |
dc.description.abstract | Spektrofotometrijski su proučavane ravnoteže u zasićenom vodenom rastvoru bifonazola u pH intervalu 4–10. Na osnovu ravnotežnih konstanti određenih u heterogenom sistemu izračunata je kiselinska konstanta (pKa = 5,72) i rastvorljivost bifonazola u funkciji kiselosti rastvora (S=10-5.79+10-(pH + 0.07)) Uticaj β-ciklodekstrina (β-CD) na rastvorljivost ispitivan je u prisustvu 10-3 i 10-4 mol/dm3 β-CD. Utvrđeno je da pri pH vrednostima većim od 8 dolazi do povećanja rastvorljivosti 2 puta (u prisustvu 10-4 mol/dm3 β-CD) i 13 puta (u prisustvu 10-3 mol/dm3 β-CD) u odnosu na rastvorljivost bifonazola u vodi (u odsustvu β-CD). Odnos rastvorljivosti bifonazola u prisustvu β-CD i rastvorljivosti u vodi smanjuje se sa povećanjem kiselosti rastvora. | sr |
dc.publisher | Srpsko hemijsko društvo, Beograd | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | bifonazole | en |
dc.subject | acidity constant | en |
dc.subject | solubility | en |
dc.subject | β-cyclodextrin | en |
dc.subject | beta-cyclodextrin | en |
dc.title | The effect of β-cyclodextrin and pH on bifonazole hydrosolubility | en |
dc.title | Uticaj β-ciklodekstrina i PH na rastvorljivost bifonazola u vodi | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Чакар, Мира; Поповић, Гордана; Утицај β-циклодекстрина и ПХ на растворљивост бифоназола у води; Утицај β-циклодекстрина и ПХ на растворљивост бифоназола у води; | |
dc.citation.volume | 69 | |
dc.citation.issue | 3 | |
dc.citation.spage | 225 | |
dc.citation.epage | 231 | |
dc.citation.other | 69(3): 225-231 | |
dc.citation.rank | M23 | |
dc.description.other | Ministarstvo nauke RS, br. 1458 | |
dc.identifier.wos | 000220461000006 | |
dc.identifier.doi | 10.2298/JSC0403225P | |
dc.identifier.scopus | 2-s2.0-2142702393 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/2063/548.pdf | |
dc.type.version | publishedVersion |