Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms
Само за регистроване кориснике
2024
Аутори
Radović, BiljanaBaralić, Katarina
Ćurčić, Marijana
Marić, Đurđica
Živanović, Jovana
Antonijević-Miljaković, Evica
Buha-Đorđević, Aleksandra
Đukić-Ćosić, Danijela
Bulat, Zorica
Antonijević, Biljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite port...al and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.
Кључне речи:
flame retardants / lead / cadmium / nickelИзвор:
Science of the Total Environment, 2024, 917, 170437-Издавач:
- Elsevier V. B.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/j.scitotenv.2024.170437
ISSN: 0048-9697
PubMed: 38290670
Scopus: 2-s2.0-85184000891
Институција/група
PharmacyTY - JOUR AU - Radović, Biljana AU - Baralić, Katarina AU - Ćurčić, Marijana AU - Marić, Đurđica AU - Živanović, Jovana AU - Antonijević-Miljaković, Evica AU - Buha-Đorđević, Aleksandra AU - Đukić-Ćosić, Danijela AU - Bulat, Zorica AU - Antonijević, Biljana PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5530 AB - The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study. PB - Elsevier V. B. T2 - Science of the Total Environment T1 - Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms VL - 917 SP - 170437 DO - 10.1016/j.scitotenv.2024.170437 ER -
@article{ author = "Radović, Biljana and Baralić, Katarina and Ćurčić, Marijana and Marić, Đurđica and Živanović, Jovana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana", year = "2024", abstract = "The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.", publisher = "Elsevier V. B.", journal = "Science of the Total Environment", title = "Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms", volume = "917", pages = "170437", doi = "10.1016/j.scitotenv.2024.170437" }
Radović, B., Baralić, K., Ćurčić, M., Marić, Đ., Živanović, J., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2024). Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms. in Science of the Total Environment Elsevier V. B.., 917, 170437. https://doi.org/10.1016/j.scitotenv.2024.170437
Radović B, Baralić K, Ćurčić M, Marić Đ, Živanović J, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Bulat Z, Antonijević B. Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms. in Science of the Total Environment. 2024;917:170437. doi:10.1016/j.scitotenv.2024.170437 .
Radović, Biljana, Baralić, Katarina, Ćurčić, Marijana, Marić, Đurđica, Živanović, Jovana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms" in Science of the Total Environment, 917 (2024):170437, https://doi.org/10.1016/j.scitotenv.2024.170437 . .