Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation
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2024
Authors
Stanković, TijanaIlić, Tanja
Petković, Miloš
Pantelić, Ivana
Dobričić, Vladimir
Cook, James M.
Savić, Miroslav
Savić, Snežana
Conference object (Published version)
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Show full item recordAbstract
The low aqueous and oil solubility of the novel
pyrazoloquinolinone ligand (CW-02-79) with significant
binding affinity for sigma-2 receptors in the brain hinders
the development of conventional parenteral formulations
and thus a comprehensive evaluation of its efficacy and
safety. ...
Keywords:
CW-02-79 / drug-phospholipid complex / nanoemulsion / pyrazoloquinolinoneSource:
14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria, 2024Publisher:
- International Society of Drug Delivery Sciences and Technology (APGI)
- International Association for Pharmaceutical Technology (APV)
- Italian Society of Technology and Legislation (S.T.E.L.F)
Funding / projects:
- NanoCellEmoCog - Neuroimmune aspects of mood, anxiety and cognitive effects of leads/drug candidates acting at GABAA and/or sigma-2 receptors: In vitro/in vivo delineation by nano- and hiPSC-based platform (RS-ScienceFundRS-Ideje-7749108)
Note:
- Poster presentation: https://farfar.pharmacy.bg.ac.rs/handle/123456789/5578
Related info:
- Referenced by
https://farfar.pharmacy.bg.ac.rs/handle/123456789/5578
Institution/Community
PharmacyTY - CONF AU - Stanković, Tijana AU - Ilić, Tanja AU - Petković, Miloš AU - Pantelić, Ivana AU - Dobričić, Vladimir AU - Cook, James M. AU - Savić, Miroslav AU - Savić, Snežana PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5577 AB - The low aqueous and oil solubility of the novel pyrazoloquinolinone ligand (CW-02-79) with significant binding affinity for sigma-2 receptors in the brain hinders the development of conventional parenteral formulations and thus a comprehensive evaluation of its efficacy and safety. ... PB - International Society of Drug Delivery Sciences and Technology (APGI) PB - International Association for Pharmaceutical Technology (APV) PB - Italian Society of Technology and Legislation (S.T.E.L.F) C3 - 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria T1 - Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation UR - https://hdl.handle.net/21.15107/rcub_farfar_5577 ER -
@conference{ author = "Stanković, Tijana and Ilić, Tanja and Petković, Miloš and Pantelić, Ivana and Dobričić, Vladimir and Cook, James M. and Savić, Miroslav and Savić, Snežana", year = "2024", abstract = "The low aqueous and oil solubility of the novel pyrazoloquinolinone ligand (CW-02-79) with significant binding affinity for sigma-2 receptors in the brain hinders the development of conventional parenteral formulations and thus a comprehensive evaluation of its efficacy and safety. ...", publisher = "International Society of Drug Delivery Sciences and Technology (APGI), International Association for Pharmaceutical Technology (APV), Italian Society of Technology and Legislation (S.T.E.L.F)", journal = "14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria", title = "Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation", url = "https://hdl.handle.net/21.15107/rcub_farfar_5577" }
Stanković, T., Ilić, T., Petković, M., Pantelić, I., Dobričić, V., Cook, J. M., Savić, M.,& Savić, S.. (2024). Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation. in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria International Society of Drug Delivery Sciences and Technology (APGI).. https://hdl.handle.net/21.15107/rcub_farfar_5577
Stanković T, Ilić T, Petković M, Pantelić I, Dobričić V, Cook JM, Savić M, Savić S. Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation. in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria. 2024;. https://hdl.handle.net/21.15107/rcub_farfar_5577 .
Stanković, Tijana, Ilić, Tanja, Petković, Miloš, Pantelić, Ivana, Dobričić, Vladimir, Cook, James M., Savić, Miroslav, Savić, Snežana, "Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation" in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria (2024), https://hdl.handle.net/21.15107/rcub_farfar_5577 .