Приказ основних података о документу
Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus
dc.creator | Toljić, Mina | |
dc.creator | Nikolić, Nađa | |
dc.creator | Joksić, Ivana | |
dc.creator | Čarkić, Jelena | |
dc.creator | Munjas, Jelena | |
dc.creator | Karadžov Orlić, Nataša | |
dc.creator | Milašin, Jelena | |
dc.date.accessioned | 2024-04-17T13:45:57Z | |
dc.date.available | 2024-04-17T13:45:57Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 0165-0378 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/5615 | |
dc.description.abstract | Altered microRNAs (miRNAs1) and cytokines expression levels are associated with several pregnancy-induced complications. We evaluated the profile of circulating miRNAs (miR-17, miR-29a and miR-181a) and proinflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-17) in women with gestational diabetes mellitus (GDM2), as well as their potential use as GDM biomarkers. The case-control study included 65 pregnant women divided into 2 groups - GDM and control. Expression levels of miRNAs in plasma samples and cytokines mRNA isolated from peripheral blood buffy coat were analyzed by quantitative real-time PCR (qPCR3). Significant miR-29a downregulation was found in GDM compared to the control group, and was even more significant after adjustments for covariates. miR-17 and miR-181a expression levels did not differ between the examined groups. Expression levels of IL-1β were significantly higher in GDM group compared to controls, while TNF-α, IL-6 and IL-17 did not show significant changes in expression between the two groups. As jugded from the ROC curve analysis, miR-29a and IL-1β had a significant capacity to discriminate between CG and GDM. Additionally, a positive correlation was established between IL-1β and TNF-α in the GDM group. GDM appeared to be associated with altered levels of miR-29a and IL-1β making them markers of this condition. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier B.V. | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200129/RS// | sr |
dc.rights | closedAccess | sr |
dc.source | Journal of Reproductive Immunology | sr |
dc.subject | Gestational diabetes mellitus | sr |
dc.subject | MicroRNA | sr |
dc.subject | Proinflamatory cytokine | sr |
dc.subject | miR-29a | sr |
dc.subject | IL-1β | sr |
dc.title | Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.citation.volume | 162 | |
dc.citation.spage | 104211 | |
dc.identifier.wos | 001184899900001 | |
dc.identifier.doi | 10.1016/j.jri.2024.104211 | |
dc.identifier.pmid | 38342070 | |
dc.identifier.scopus | 2-s2.0-85184899258 | |
dc.type.version | publishedVersion | sr |