Приказ основних података о документу
Effects of various nitric oxide synthase inhibitors on quinolinic acid-induced neuronal injury in rats
Efekti različitih inhibitora azot oksid sintaze na oštećenje neurona indukovano hinolinskom kiselinom kod pacova
dc.creator | Vasiljević, Ivana D. | |
dc.creator | Jovanović, Marina | |
dc.creator | Čolić, Miodrag | |
dc.creator | Mihajlović, Rosa | |
dc.creator | Đukić, Mirjana | |
dc.creator | Ninković, Milica | |
dc.creator | Maličević, Živorad | |
dc.date.accessioned | 2019-09-02T11:00:12Z | |
dc.date.available | 2019-09-02T11:00:12Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0354-3447 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/562 | |
dc.description.abstract | The aetiology of neuronal death in neurodegenerative diseases, including Huntington-s disease, is still unknown. There could be a complex interplay among altered energy metabolism, excitotoxicity and oxidative stress. Our aim was to examine the effects of intrastriatal injection of a selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, and a non-specific potent nitric oxide synthase inhibitor, Nw-nitro-L-arginine methyl ester, in order to study the possible involvement of glutathione, an important antioxidant, in quinolinic acid-induced striatal toxicity in the rat. Unilateral administration of quinolinic acid to rat striatum in a single dose of 150 nmol/L was used as a model of Huntington-s disease. The other group of animals were pretreated with 7- nitroindazole and Nw-nitro-L-arginine methyl ester, respectively. Control groups were treated with saline solution and olive oil, respectively. Content of total glutathione, was increased in the ipsi- and contralateral striatum, forebrain cortex, basal forebrain and hippocampus in the groups treated with nitric oxid synthase inhibitors and quinolinic acid compared to the quinolinic acid-treated animals. These results support the hypothesis that oxygen free radicals contribute to excitotoxic neuronal injury, and also that nitric oxide synthase inhibitors could be potential neuroprotective agents in Huntington-s disease. | en |
dc.description.abstract | Etiologija selektivnog umiranja neurona u neurodegenerativnim bolestima je nepoznata, iako postoje dokazi o defektu energetskog metabolizma, ekscitotoksičnosti i oksidativnom oštećenju. Verovatno je da ključnu ulogu ima kompleksna interakcija između ovih mehanizama. Cilj ovog rada bio je da se ispitaju efekti intrastrijatne primene selektivnog inhibitora neuronske azot oksid sintaze, 7-nitroindazola, kao i nespecifičnog inhibitora azot oksid sintaze, Nw-nitro-l-arginin metil estra, zbog moguće uključenosti glutationa, ključnog antioksidansa, u toksičnost strijatuma izazvanu hinolinskom kiselinom, kod pacova. Unilateralna aplikacija hinolinske kiseline, u strijatum pacova u pojedinačnoj dozi od 150 nmol/L korišćena je kao model Hantingtonove bolesti. Druge grupe životinja tretirane su 7-nitroindazolom, odnosno Nw-nitro-l-arginin metil estrom. Kontrolne grupe dobijale su fiziološki rastvor, odnosno maslinovo ulje. Sadržaj ukupnog glutationa je povećan u ipsi- i kontralateralnom strijatumu, kori prednjeg mozga, bazalnom prednjem mozgu i hipokampusu grupa životinja koje su pored hinolinske kiseline primile i odgovarajući inhibitor neuronske azot oksid sintaze, u poređenju sa grupom tretiranom samo neurotoksinom. Ovi podaci pokazuju da kiseonični slobodni radikali učestvuju u ekscitotoksičnom oštećenju neurona, kao i da inhibitori azot oksid sintaze mogu biti potencijalni neuroprotektivni agensi u Hantingtonovoj bolesti. | sr |
dc.publisher | Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd | |
dc.rights | openAccess | |
dc.source | Jugoslovenska medicinska biohemija | |
dc.subject | Huntington-s disease | en |
dc.subject | quinolinic acid | en |
dc.subject | Nw-nitro-L-arginine methyl ester | en |
dc.subject | 7-nitroindazole | en |
dc.subject | glutathione | en |
dc.subject | Hantingtonova bolest | sr |
dc.subject | hinolinska kiselina | sr |
dc.subject | Nw-nitro-l-arginin metil estar | sr |
dc.subject | 7-nitroindazol | sr |
dc.subject | glutation | sr |
dc.title | Effects of various nitric oxide synthase inhibitors on quinolinic acid-induced neuronal injury in rats | en |
dc.title | Efekti različitih inhibitora azot oksid sintaze na oštećenje neurona indukovano hinolinskom kiselinom kod pacova | sr |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Чолић, Миодраг; Нинковић, Милица; Михајловић, Роса; Васиљевић, Ивана; Маличевић, Живорад; Ђукић, Мирјана; Јовановић, Марина; Ефекти различитих инхибитора азот оксид синтазе на оштећење неурона индуковано хинолинском киселином код пацова; Ефекти различитих инхибитора азот оксид синтазе на оштећење неурона индуковано хинолинском киселином код пацова; | |
dc.citation.volume | 23 | |
dc.citation.issue | 1 | |
dc.citation.spage | 11 | |
dc.citation.epage | 18 | |
dc.citation.other | 23(1): 11-18 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.2298/JMH0401011V | |
dc.identifier.scopus | 2-s2.0-1842427441 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/2076/560.pdf | |
dc.type.version | publishedVersion |