Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos

Abstract

The aim of the present work was to examine potential beneficial role of sodium bicarbonate (3 mmol/kg ip) on protective potency of trimedoxime (10 mg/kg im), obidoxime (10 mg/kg im) and atropine (10 mg/kg im) in rats poisoned with dichlorvos. Special attention was paid to the influence of co-administration of sodium bicarbonate on acid-base status in experimental animals poisoned with dichlorvos (1.3 LD50 sc). Coadministration of sodium bicarbonate significantly increased protective effect of standard antidotes in rats poisoned with dichlorvos. Sodium bicarbonate given along with atropine/oxime produced an increase in blood pH value and correction of acidosis. In conclusion, correlation between protective effect and biochemical outcome was evident when sodium bicarbonate was added to antidotes.

Cilj rada je bio da se ispita efekat natrijum bikarbonata (3 mmol/kg ip) na zaštitni potencijal trimedoksima (10 mg/kg im), obidoksima (10 mg/kg im) i atropina (10 mg/kg im) u pacova trovanih dihlorvosom. Posebna pažnja je posvećena uticaju kombinacija natrijum bikarbonata i antidota na acido-bazni status eksperimentalnih životinja trovanih dihlorvosom (1.3 LD50 ). Primena kombinacija sa natrijum bikarbonatom zna- čajno je povećala zaštitne efekte standardnih antidota, a došlo je i do porasta vrednosti pH krvi i korekcije acidoze. Takođe, moglo se zaključiti da kada je natrijum bikarbonat dat zajedno sa atropinom/oksimom postoji jasna korelacija između dobijenih zaštitnih efekata i testiranih biohemijskih parametara.