Beneficial effects of a new probiotic formulation on adipocytokines, appetite-regulating hormones, and metabolic parameters in obese women
Само за регистроване кориснике
2024
Аутори
Okuka, NinaMilinković, Neda
Veličković, Ksenija
Polovina, Snežana
Šumarac-Dumanović, Mirjana
Minić, Rajna
Korčok, Davor
Đorđević, Brižita
Ivanović, Nevena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Obesity is often accompanied by low-grade chronic inflammation and metabolic syndrome. It has been established that microbiota influences many physiological processes, including the development of obesity, and dysbiosis has been observed in obese individuals. In this study, we aimed to evaluate the impact of a new probiotic formulation, containing two probiotic strains and the bioactive compound octacosanol, on body weight, metabolic parameters, and concentrations of certain adipocytokines and appetite-regulating hormones in obese women. This double blind placebo-controlled supplementary intervention study included twenty-five women in the intervention group and twenty-three in the placebo group, and it lasted 12 weeks. Daily oral supplementation included 7 × 1010 CFU of Lactiplantibacillus plantarum 299v (DSM9843), 5 × 109 CFU of Saccharomyces cerevisiae var. boulardii (DBVPG6763), and 40 mg of octacosanol or placebo. Body weight, metabolic parameters, adipocytokines, and appetite-reg...ulating hormones were assessed before (T0) and after the intervention (T1). After the intervention, significantly lower median concentrations of CRP (p = 0.005) and IL-6 (p = 0.012) were measured in the intervention group than the baseline, while the median concentrations of ghrelin (p = 0.026) and HDL-cholesterol (p = 0.03) were significantly increased. The intervention group had lower CRP levels (p = 0.023) and higher ghrelin levels (p = 0.006) than the placebo group. Significant changes in BMI between groups were not observed. In summary, although the new probiotic formulation showed beneficial effects on IL-6, CRP, HDL, and ghrelin levels, its potential effects on regulating triglyceride, insulin, and glucose levels require further studies before the novel dietary intervention could be considered a useful adjuvant therapy and an effective strategy for the management of obesity and obesity-associated comorbidities. © 2024 The Royal Society of Chemistry.
Извор:
Food and Function, 2024, 15, 14, 7658-7668Издавач:
- Royal Society of Chemistry
Финансирање / пројекти:
- The Ministry of Education, Science, and Technological Development, the Republic of Serbia, through a bilateral project with Austria, Grant No.: 451- 03-02141/2017-09/35
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.1039/d4fo01269k
ISSN: 2042-6496
PubMed: 38953736
WoS: 001260030500001
Scopus: 2-s2.0-85197610455
Институција/група
PharmacyTY - JOUR AU - Okuka, Nina AU - Milinković, Neda AU - Veličković, Ksenija AU - Polovina, Snežana AU - Šumarac-Dumanović, Mirjana AU - Minić, Rajna AU - Korčok, Davor AU - Đorđević, Brižita AU - Ivanović, Nevena PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5699 AB - Obesity is often accompanied by low-grade chronic inflammation and metabolic syndrome. It has been established that microbiota influences many physiological processes, including the development of obesity, and dysbiosis has been observed in obese individuals. In this study, we aimed to evaluate the impact of a new probiotic formulation, containing two probiotic strains and the bioactive compound octacosanol, on body weight, metabolic parameters, and concentrations of certain adipocytokines and appetite-regulating hormones in obese women. This double blind placebo-controlled supplementary intervention study included twenty-five women in the intervention group and twenty-three in the placebo group, and it lasted 12 weeks. Daily oral supplementation included 7 × 1010 CFU of Lactiplantibacillus plantarum 299v (DSM9843), 5 × 109 CFU of Saccharomyces cerevisiae var. boulardii (DBVPG6763), and 40 mg of octacosanol or placebo. Body weight, metabolic parameters, adipocytokines, and appetite-regulating hormones were assessed before (T0) and after the intervention (T1). After the intervention, significantly lower median concentrations of CRP (p = 0.005) and IL-6 (p = 0.012) were measured in the intervention group than the baseline, while the median concentrations of ghrelin (p = 0.026) and HDL-cholesterol (p = 0.03) were significantly increased. The intervention group had lower CRP levels (p = 0.023) and higher ghrelin levels (p = 0.006) than the placebo group. Significant changes in BMI between groups were not observed. In summary, although the new probiotic formulation showed beneficial effects on IL-6, CRP, HDL, and ghrelin levels, its potential effects on regulating triglyceride, insulin, and glucose levels require further studies before the novel dietary intervention could be considered a useful adjuvant therapy and an effective strategy for the management of obesity and obesity-associated comorbidities. © 2024 The Royal Society of Chemistry. PB - Royal Society of Chemistry T2 - Food and Function T1 - Beneficial effects of a new probiotic formulation on adipocytokines, appetite-regulating hormones, and metabolic parameters in obese women VL - 15 IS - 14 SP - 7658 EP - 7668 DO - 10.1039/d4fo01269k ER -
@article{ author = "Okuka, Nina and Milinković, Neda and Veličković, Ksenija and Polovina, Snežana and Šumarac-Dumanović, Mirjana and Minić, Rajna and Korčok, Davor and Đorđević, Brižita and Ivanović, Nevena", year = "2024", abstract = "Obesity is often accompanied by low-grade chronic inflammation and metabolic syndrome. It has been established that microbiota influences many physiological processes, including the development of obesity, and dysbiosis has been observed in obese individuals. In this study, we aimed to evaluate the impact of a new probiotic formulation, containing two probiotic strains and the bioactive compound octacosanol, on body weight, metabolic parameters, and concentrations of certain adipocytokines and appetite-regulating hormones in obese women. This double blind placebo-controlled supplementary intervention study included twenty-five women in the intervention group and twenty-three in the placebo group, and it lasted 12 weeks. Daily oral supplementation included 7 × 1010 CFU of Lactiplantibacillus plantarum 299v (DSM9843), 5 × 109 CFU of Saccharomyces cerevisiae var. boulardii (DBVPG6763), and 40 mg of octacosanol or placebo. Body weight, metabolic parameters, adipocytokines, and appetite-regulating hormones were assessed before (T0) and after the intervention (T1). After the intervention, significantly lower median concentrations of CRP (p = 0.005) and IL-6 (p = 0.012) were measured in the intervention group than the baseline, while the median concentrations of ghrelin (p = 0.026) and HDL-cholesterol (p = 0.03) were significantly increased. The intervention group had lower CRP levels (p = 0.023) and higher ghrelin levels (p = 0.006) than the placebo group. Significant changes in BMI between groups were not observed. In summary, although the new probiotic formulation showed beneficial effects on IL-6, CRP, HDL, and ghrelin levels, its potential effects on regulating triglyceride, insulin, and glucose levels require further studies before the novel dietary intervention could be considered a useful adjuvant therapy and an effective strategy for the management of obesity and obesity-associated comorbidities. © 2024 The Royal Society of Chemistry.", publisher = "Royal Society of Chemistry", journal = "Food and Function", title = "Beneficial effects of a new probiotic formulation on adipocytokines, appetite-regulating hormones, and metabolic parameters in obese women", volume = "15", number = "14", pages = "7658-7668", doi = "10.1039/d4fo01269k" }
Okuka, N., Milinković, N., Veličković, K., Polovina, S., Šumarac-Dumanović, M., Minić, R., Korčok, D., Đorđević, B.,& Ivanović, N.. (2024). Beneficial effects of a new probiotic formulation on adipocytokines, appetite-regulating hormones, and metabolic parameters in obese women. in Food and Function Royal Society of Chemistry., 15(14), 7658-7668. https://doi.org/10.1039/d4fo01269k
Okuka N, Milinković N, Veličković K, Polovina S, Šumarac-Dumanović M, Minić R, Korčok D, Đorđević B, Ivanović N. Beneficial effects of a new probiotic formulation on adipocytokines, appetite-regulating hormones, and metabolic parameters in obese women. in Food and Function. 2024;15(14):7658-7668. doi:10.1039/d4fo01269k .
Okuka, Nina, Milinković, Neda, Veličković, Ksenija, Polovina, Snežana, Šumarac-Dumanović, Mirjana, Minić, Rajna, Korčok, Davor, Đorđević, Brižita, Ivanović, Nevena, "Beneficial effects of a new probiotic formulation on adipocytokines, appetite-regulating hormones, and metabolic parameters in obese women" in Food and Function, 15, no. 14 (2024):7658-7668, https://doi.org/10.1039/d4fo01269k . .