A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.
TY - JOUR
AU - Lučić, Branka
AU - Radulović, Dušanka
AU - Vujić, Zorica
AU - Agbaba, Danica
PY - 2005
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/570
AB - A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.
PB - Research Inst Medicinal Plants, Budakalasz
T2 - Journal of Planar Chromatography - Modern TLC
T1 - Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector
VL - 18
IS - 104
SP - 294
EP - 299
DO - 10.1556/JPC.18.2005.4.8
ER -
@article{
author = "Lučić, Branka and Radulović, Dušanka and Vujić, Zorica and Agbaba, Danica",
year = "2005",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/570",
abstract = "A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector",
volume = "18",
number = "104",
pages = "294-299",
doi = "10.1556/JPC.18.2005.4.8"
}
Lučić, B., Radulović, D., Vujić, Z.,& Agbaba, D. (2005). Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector.
Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 18(104), 294-299.
https://doi.org/10.1556/JPC.18.2005.4.8
Lučić B, Radulović D, Vujić Z, Agbaba D. Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector. Journal of Planar Chromatography - Modern TLC. 2005;18(104):294-299
Lučić Branka, Radulović Dušanka, Vujić Zorica, Agbaba Danica, "Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector" Journal of Planar Chromatography - Modern TLC, 18, no. 104 (2005):294-299,
https://doi.org/10.1556/JPC.18.2005.4.8 .
