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Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector

Authorized Users Only
2005
Authors
Lučić, Branka
Radulović, Dušanka
Vujić, Zorica
Agbaba, Danica
Article (Published version)
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Abstract
A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.
Keywords:
TLC / chiral separation / metoprolol tartrate / D-(-)-tartaric acid
Source:
Journal of Planar Chromatography - Modern TLC, 2005, 18, 104, 294-299
Publisher:
  • Research Inst Medicinal Plants, Budakalasz

DOI: 10.1556/JPC.18.2005.4.8

ISSN: 0933-4173

WoS: 000231689200008

Scopus: 2-s2.0-24344454332
[ Google Scholar ]
21
16
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/570
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Lučić, Branka
AU  - Radulović, Dušanka
AU  - Vujić, Zorica
AU  - Agbaba, Danica
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/570
AB  - A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector
VL  - 18
IS  - 104
SP  - 294
EP  - 299
DO  - 10.1556/JPC.18.2005.4.8
ER  - 
@article{
author = "Lučić, Branka and Radulović, Dušanka and Vujić, Zorica and Agbaba, Danica",
year = "2005",
abstract = "A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector",
volume = "18",
number = "104",
pages = "294-299",
doi = "10.1556/JPC.18.2005.4.8"
}
Lučić, B., Radulović, D., Vujić, Z.,& Agbaba, D.. (2005). Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector. in Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 18(104), 294-299.
https://doi.org/10.1556/JPC.18.2005.4.8
Lučić B, Radulović D, Vujić Z, Agbaba D. Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector. in Journal of Planar Chromatography - Modern TLC. 2005;18(104):294-299.
doi:10.1556/JPC.18.2005.4.8 .
Lučić, Branka, Radulović, Dušanka, Vujić, Zorica, Agbaba, Danica, "Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector" in Journal of Planar Chromatography - Modern TLC, 18, no. 104 (2005):294-299,
https://doi.org/10.1556/JPC.18.2005.4.8 . .

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