Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment
Само за регистроване кориснике
2005
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this paper, there was developed a sensitive, precise and accurate reversed-phase liquid chromatographic (RP-HPLC) method and validated for simultaneous determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment. Also there was achieved a parallel analysis of buthylhydroxyanisol, as a preservative, and hydroquinone, as a degradation product of calcium dobesilate, present in these dosage forms. The relative standard deviation (RSD) values for all five compounds indicated a good precision and accuracy of the RP-HPLC method. Method is selective, sensitive and reproducible with good recovery values and can be applied in simultaneous determination of all mentioned compounds.
Кључне речи:
liquid chromatography / validation / lidocaine hydrochloride / dexamethasone acetate / calcium dobesilate / buthylhydroxyanisol / hydroquinoneИзвор:
Journal of Chromatography A, 2005, 1088, 1-2, 182-186Издавач:
- Elsevier Science BV, Amsterdam
DOI: 10.1016/j.chroma.2005.04.049
ISSN: 0021-9673
PubMed: 16130749
WoS: 000231185900023
Scopus: 2-s2.0-23044514374
Институција/група
PharmacyTY - JOUR AU - Živanović, L AU - Zečević, Mira AU - Marković, S AU - Petrović, S AU - Ivanović, I PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/573 AB - In this paper, there was developed a sensitive, precise and accurate reversed-phase liquid chromatographic (RP-HPLC) method and validated for simultaneous determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment. Also there was achieved a parallel analysis of buthylhydroxyanisol, as a preservative, and hydroquinone, as a degradation product of calcium dobesilate, present in these dosage forms. The relative standard deviation (RSD) values for all five compounds indicated a good precision and accuracy of the RP-HPLC method. Method is selective, sensitive and reproducible with good recovery values and can be applied in simultaneous determination of all mentioned compounds. PB - Elsevier Science BV, Amsterdam T2 - Journal of Chromatography A T1 - Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment VL - 1088 IS - 1-2 SP - 182 EP - 186 DO - 10.1016/j.chroma.2005.04.049 ER -
@article{ author = "Živanović, L and Zečević, Mira and Marković, S and Petrović, S and Ivanović, I", year = "2005", abstract = "In this paper, there was developed a sensitive, precise and accurate reversed-phase liquid chromatographic (RP-HPLC) method and validated for simultaneous determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment. Also there was achieved a parallel analysis of buthylhydroxyanisol, as a preservative, and hydroquinone, as a degradation product of calcium dobesilate, present in these dosage forms. The relative standard deviation (RSD) values for all five compounds indicated a good precision and accuracy of the RP-HPLC method. Method is selective, sensitive and reproducible with good recovery values and can be applied in simultaneous determination of all mentioned compounds.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Chromatography A", title = "Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment", volume = "1088", number = "1-2", pages = "182-186", doi = "10.1016/j.chroma.2005.04.049" }
Živanović, L., Zečević, M., Marković, S., Petrović, S.,& Ivanović, I.. (2005). Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment. in Journal of Chromatography A Elsevier Science BV, Amsterdam., 1088(1-2), 182-186. https://doi.org/10.1016/j.chroma.2005.04.049
Živanović L, Zečević M, Marković S, Petrović S, Ivanović I. Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment. in Journal of Chromatography A. 2005;1088(1-2):182-186. doi:10.1016/j.chroma.2005.04.049 .
Živanović, L, Zečević, Mira, Marković, S, Petrović, S, Ivanović, I, "Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment" in Journal of Chromatography A, 1088, no. 1-2 (2005):182-186, https://doi.org/10.1016/j.chroma.2005.04.049 . .