Show simple item record

dc.creatorŽivanović, L
dc.creatorZečević, Mira
dc.creatorMarković, S
dc.creatorPetrović, S
dc.creatorIvanović, I
dc.date.accessioned2019-09-02T11:00:31Z
dc.date.available2019-09-02T11:00:31Z
dc.date.issued2005
dc.identifier.issn0021-9673
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/573
dc.description.abstractIn this paper, there was developed a sensitive, precise and accurate reversed-phase liquid chromatographic (RP-HPLC) method and validated for simultaneous determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment. Also there was achieved a parallel analysis of buthylhydroxyanisol, as a preservative, and hydroquinone, as a degradation product of calcium dobesilate, present in these dosage forms. The relative standard deviation (RSD) values for all five compounds indicated a good precision and accuracy of the RP-HPLC method. Method is selective, sensitive and reproducible with good recovery values and can be applied in simultaneous determination of all mentioned compounds.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography A
dc.subjectliquid chromatographyen
dc.subjectvalidationen
dc.subjectlidocaine hydrochlorideen
dc.subjectdexamethasone acetateen
dc.subjectcalcium dobesilateen
dc.subjectbuthylhydroxyanisolen
dc.subjecthydroquinoneen
dc.titleValidation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointmenten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗечевић, Мира; Ивановић, И; Живановић, Л; Петровић, С; Марковић, С;
dc.citation.volume1088
dc.citation.issue1-2
dc.citation.spage182
dc.citation.epage186
dc.citation.other1088(1-2): 182-186
dc.citation.rankaM21
dc.identifier.wos000231185900023
dc.identifier.doi10.1016/j.chroma.2005.04.049
dc.identifier.pmid16130749
dc.identifier.scopus2-s2.0-23044514374
dc.identifier.rcubconv_1652
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record