Development of a HPTLC method for in-process purity testing of pentoxifylline
Само за регистроване кориснике
2005
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A HPTLC method for the separation and identification of pentoxifylline and related substances, impurities of reaction partners, and side reaction products has been developed using different mobile and stationary phases. For quantitative assay of possible by-products as impurities, LiChrosphere (R) RP-18 F254s chromatoplates, acetone-chloroform-toluene-dioxane (221:11 v/v) as a mobile phase, and detection at 275 nm were employed. Linearity (r >= 0.997), recovery (86.5-115.5%), and determination limit (0.1-0.6%) were evaluated and found to be satisfactory. This method enables monitoring of the synthesis, as well as purity control of pentoxifylline-containing raw materials and pharmaceuticals.
Кључне речи:
pentoxifylline / HPTLC / impurities / quantitationИзвор:
Journal of Separation Science, 2005, 28, 6, 575-580Издавач:
- Wiley-VCH Verlag GMBH, Weinheim
DOI: 10.1002/jssc.200400006
ISSN: 1615-9306
PubMed: 15881088
WoS: 000228760400011
Scopus: 2-s2.0-17844371309
Институција/група
PharmacyTY - JOUR AU - Grozdanović, Olivera AU - Antić, Dušan AU - Agbaba, Danica PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/587 AB - A HPTLC method for the separation and identification of pentoxifylline and related substances, impurities of reaction partners, and side reaction products has been developed using different mobile and stationary phases. For quantitative assay of possible by-products as impurities, LiChrosphere (R) RP-18 F254s chromatoplates, acetone-chloroform-toluene-dioxane (221:11 v/v) as a mobile phase, and detection at 275 nm were employed. Linearity (r >= 0.997), recovery (86.5-115.5%), and determination limit (0.1-0.6%) were evaluated and found to be satisfactory. This method enables monitoring of the synthesis, as well as purity control of pentoxifylline-containing raw materials and pharmaceuticals. PB - Wiley-VCH Verlag GMBH, Weinheim T2 - Journal of Separation Science T1 - Development of a HPTLC method for in-process purity testing of pentoxifylline VL - 28 IS - 6 SP - 575 EP - 580 DO - 10.1002/jssc.200400006 ER -
@article{ author = "Grozdanović, Olivera and Antić, Dušan and Agbaba, Danica", year = "2005", abstract = "A HPTLC method for the separation and identification of pentoxifylline and related substances, impurities of reaction partners, and side reaction products has been developed using different mobile and stationary phases. For quantitative assay of possible by-products as impurities, LiChrosphere (R) RP-18 F254s chromatoplates, acetone-chloroform-toluene-dioxane (221:11 v/v) as a mobile phase, and detection at 275 nm were employed. Linearity (r >= 0.997), recovery (86.5-115.5%), and determination limit (0.1-0.6%) were evaluated and found to be satisfactory. This method enables monitoring of the synthesis, as well as purity control of pentoxifylline-containing raw materials and pharmaceuticals.", publisher = "Wiley-VCH Verlag GMBH, Weinheim", journal = "Journal of Separation Science", title = "Development of a HPTLC method for in-process purity testing of pentoxifylline", volume = "28", number = "6", pages = "575-580", doi = "10.1002/jssc.200400006" }
Grozdanović, O., Antić, D.,& Agbaba, D.. (2005). Development of a HPTLC method for in-process purity testing of pentoxifylline. in Journal of Separation Science Wiley-VCH Verlag GMBH, Weinheim., 28(6), 575-580. https://doi.org/10.1002/jssc.200400006
Grozdanović O, Antić D, Agbaba D. Development of a HPTLC method for in-process purity testing of pentoxifylline. in Journal of Separation Science. 2005;28(6):575-580. doi:10.1002/jssc.200400006 .
Grozdanović, Olivera, Antić, Dušan, Agbaba, Danica, "Development of a HPTLC method for in-process purity testing of pentoxifylline" in Journal of Separation Science, 28, no. 6 (2005):575-580, https://doi.org/10.1002/jssc.200400006 . .