Development of a HPTLC method for in-process purity testing of pentoxifylline
Samo za registrovane korisnike
2005
Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A HPTLC method for the separation and identification of pentoxifylline and related substances, impurities of reaction partners, and side reaction products has been developed using different mobile and stationary phases. For quantitative assay of possible by-products as impurities, LiChrosphere (R) RP-18 F254s chromatoplates, acetone-chloroform-toluene-dioxane (221:11 v/v) as a mobile phase, and detection at 275 nm were employed. Linearity (r >= 0.997), recovery (86.5-115.5%), and determination limit (0.1-0.6%) were evaluated and found to be satisfactory. This method enables monitoring of the synthesis, as well as purity control of pentoxifylline-containing raw materials and pharmaceuticals.
Ključne reči:
pentoxifylline / HPTLC / impurities / quantitationIzvor:
Journal of Separation Science, 2005, 28, 6, 575-580Izdavač:
- Wiley-VCH Verlag GMBH, Weinheim
DOI: 10.1002/jssc.200400006
ISSN: 1615-9306
PubMed: 15881088