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dc.creatorGrozdanović, Olivera
dc.creatorAntić, Dušan
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T11:00:49Z
dc.date.available2019-09-02T11:00:49Z
dc.date.issued2005
dc.identifier.issn1615-9306
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/587
dc.description.abstractA HPTLC method for the separation and identification of pentoxifylline and related substances, impurities of reaction partners, and side reaction products has been developed using different mobile and stationary phases. For quantitative assay of possible by-products as impurities, LiChrosphere (R) RP-18 F254s chromatoplates, acetone-chloroform-toluene-dioxane (221:11 v/v) as a mobile phase, and detection at 275 nm were employed. Linearity (r >= 0.997), recovery (86.5-115.5%), and determination limit (0.1-0.6%) were evaluated and found to be satisfactory. This method enables monitoring of the synthesis, as well as purity control of pentoxifylline-containing raw materials and pharmaceuticals.en
dc.publisherWiley-VCH Verlag GMBH, Weinheim
dc.rightsrestrictedAccess
dc.sourceJournal of Separation Science
dc.subjectpentoxifyllineen
dc.subjectHPTLCen
dc.subjectimpuritiesen
dc.subjectquantitationen
dc.titleDevelopment of a HPTLC method for in-process purity testing of pentoxifyllineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAнтић, Д; Aгбаба, Даница; Гроздановић, О;
dc.citation.volume28
dc.citation.issue6
dc.citation.spage575
dc.citation.epage580
dc.citation.other28(6): 575-580
dc.citation.rankM22
dc.identifier.wos000228760400011
dc.identifier.doi10.1002/jssc.200400006
dc.identifier.pmid15881088
dc.identifier.scopus2-s2.0-17844371309
dc.identifier.rcubconv_1618
dc.type.versionpublishedVersion


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