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Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC

Authorized Users Only
2005
Authors
Čudina, Olivera
Comor, Mirjana
Janković, IA
Article (Published version)
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Abstract
A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations.
Keywords:
column liquid chromatography / pharmaceutical formulations / benzyl alcohol / bifonazole
Source:
Chromatographia, 2005, 61, 7-8, 415-418
Publisher:
  • Springer Heidelberg, Heidelberg

DOI: 10.1365/s10337-005-0524-9

ISSN: 0009-5893

WoS: 000228610300019

Scopus: 2-s2.0-17644393561
[ Google Scholar ]
4
3
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/588
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Čudina, Olivera
AU  - Comor, Mirjana
AU  - Janković, IA
PY  - 2005
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/588
AB  - A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations.
PB  - Springer Heidelberg, Heidelberg
T2  - Chromatographia
T1  - Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC
VL  - 61
IS  - 7-8
SP  - 415
EP  - 418
DO  - 10.1365/s10337-005-0524-9
ER  - 
@article{
author = "Čudina, Olivera and Comor, Mirjana and Janković, IA",
year = "2005",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/588",
abstract = "A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC",
volume = "61",
number = "7-8",
pages = "415-418",
doi = "10.1365/s10337-005-0524-9"
}
Čudina O, Comor M, Janković I. Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC. Chromatographia. 2005;61(7-8):415-418
Čudina, O., Comor, M.,& Janković, I. (2005). Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC.
ChromatographiaSpringer Heidelberg, Heidelberg., 61(7-8), 415-418.
https://doi.org/10.1365/s10337-005-0524-9
Čudina Olivera, Comor Mirjana, Janković IA, "Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC" 61, no. 7-8 (2005):415-418,
https://doi.org/10.1365/s10337-005-0524-9 .

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