The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 mu g/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 mu g/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05
TY - JOUR
AU - Kundaković, Tatjana
AU - Stanojković, Tatjana
AU - Juranić, Zorica
AU - Kovačević, Nada
PY - 2005
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/590
AB - The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 mu g/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 mu g/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05
PB - Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn
T2 - Pharmazie
T1 - Cytotoxic and antioxidant activity of Achillea alexandri-regis
VL - 60
IS - 4
SP - 319
EP - 320
UR - https://hdl.handle.net/21.15107/rcub_farfar_590
ER -
@article{
author = "Kundaković, Tatjana and Stanojković, Tatjana and Juranić, Zorica and Kovačević, Nada",
year = "2005",
abstract = "The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 mu g/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 mu g/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05",
publisher = "Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Cytotoxic and antioxidant activity of Achillea alexandri-regis",
volume = "60",
number = "4",
pages = "319-320",
url = "https://hdl.handle.net/21.15107/rcub_farfar_590"
}
Kundaković, T., Stanojković, T., Juranić, Z.,& Kovačević, N.. (2005). Cytotoxic and antioxidant activity of Achillea alexandri-regis. in Pharmazie
Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn., 60(4), 319-320.
https://hdl.handle.net/21.15107/rcub_farfar_590
Kundaković T, Stanojković T, Juranić Z, Kovačević N. Cytotoxic and antioxidant activity of Achillea alexandri-regis. in Pharmazie. 2005;60(4):319-320.
https://hdl.handle.net/21.15107/rcub_farfar_590 .
Kundaković, Tatjana, Stanojković, Tatjana, Juranić, Zorica, Kovačević, Nada, "Cytotoxic and antioxidant activity of Achillea alexandri-regis" in Pharmazie, 60, no. 4 (2005):319-320,
https://hdl.handle.net/21.15107/rcub_farfar_590 .
