Cytotoxic and antioxidant activity of Achillea alexandri-regis
Apstrakt
The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 mu g/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 mu g/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05
Izvor:
Pharmazie, 2005, 60, 4, 319-320Izdavač:
- Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn
Institucija/grupa
PharmacyTY - JOUR AU - Kundaković, Tatjana AU - Stanojković, Tatjana AU - Juranić, Zorica AU - Kovačević, Nada PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/590 AB - The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 mu g/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 mu g/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05 PB - Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn T2 - Pharmazie T1 - Cytotoxic and antioxidant activity of Achillea alexandri-regis VL - 60 IS - 4 SP - 319 EP - 320 UR - https://hdl.handle.net/21.15107/rcub_farfar_590 ER -
@article{ author = "Kundaković, Tatjana and Stanojković, Tatjana and Juranić, Zorica and Kovačević, Nada", year = "2005", abstract = "The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 mu g/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 mu g/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05", publisher = "Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn", journal = "Pharmazie", title = "Cytotoxic and antioxidant activity of Achillea alexandri-regis", volume = "60", number = "4", pages = "319-320", url = "https://hdl.handle.net/21.15107/rcub_farfar_590" }
Kundaković, T., Stanojković, T., Juranić, Z.,& Kovačević, N.. (2005). Cytotoxic and antioxidant activity of Achillea alexandri-regis. in Pharmazie Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn., 60(4), 319-320. https://hdl.handle.net/21.15107/rcub_farfar_590
Kundaković T, Stanojković T, Juranić Z, Kovačević N. Cytotoxic and antioxidant activity of Achillea alexandri-regis. in Pharmazie. 2005;60(4):319-320. https://hdl.handle.net/21.15107/rcub_farfar_590 .
Kundaković, Tatjana, Stanojković, Tatjana, Juranić, Zorica, Kovačević, Nada, "Cytotoxic and antioxidant activity of Achillea alexandri-regis" in Pharmazie, 60, no. 4 (2005):319-320, https://hdl.handle.net/21.15107/rcub_farfar_590 .