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Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide

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2005
Authors
Čudina, Olivera
Karljiković-Rajić, Katarina
Ruvarac-Bugarcić, I
Janković, I
Article (Published version)
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Abstract
In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(...4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3).

Keywords:
hydrochlorothiazide / CTAB / micelles / binding constant / partition coefficient
Source:
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2005, 256, 2-3, 225-232
Publisher:
  • Elsevier Science BV, Amsterdam

DOI: 10.1016/j.colsurfa.2005.01.023

ISSN: 0927-7757

WoS: 000228322800018

Scopus: 2-s2.0-14844300859
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/592
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Institution
Pharmacy

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