In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(...4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3).
TY - JOUR
AU - Čudina, Olivera
AU - Karljiković-Rajić, Katarina
AU - Ruvarac-Bugarcić, I
AU - Janković, I
PY - 2005
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/592
AB - In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3).
PB - Elsevier Science BV, Amsterdam
T2 - Colloids and Surfaces A: Physicochemical and Engineering Aspects
T1 - Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide
VL - 256
IS - 2-3
SP - 225
EP - 232
DO - 10.1016/j.colsurfa.2005.01.023
ER -
@article{
author = "Čudina, Olivera and Karljiković-Rajić, Katarina and Ruvarac-Bugarcić, I and Janković, I",
year = "2005",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/592",
abstract = "In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3).",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
title = "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide",
volume = "256",
number = "2-3",
pages = "225-232",
doi = "10.1016/j.colsurfa.2005.01.023"
}
Čudina, O., Karljiković-Rajić, K., Ruvarac-Bugarcić, I.,& Janković, I. (2005). Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide.
Colloids and Surfaces A: Physicochemical and Engineering Aspects
Elsevier Science BV, Amsterdam., 256(2-3), 225-232.
https://doi.org/10.1016/j.colsurfa.2005.01.023
Čudina O, Karljiković-Rajić K, Ruvarac-Bugarcić I, Janković I. Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2005;256(2-3):225-232
Čudina Olivera, Karljiković-Rajić Katarina, Ruvarac-Bugarcić I, Janković I, "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide" Colloids and Surfaces A: Physicochemical and Engineering Aspects, 256, no. 2-3 (2005):225-232,
https://doi.org/10.1016/j.colsurfa.2005.01.023 .
