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dc.creatorMilenković, Marina
dc.creatorVučićević, Dragana
dc.creatorMilosavljević, P
dc.creatorArsenović-Ranin, Nevena
dc.creatorStojić-Vukanić, Zorica
dc.creatorČolić, Miodrag
dc.date.accessioned2019-09-02T11:01:04Z
dc.date.available2019-09-02T11:01:04Z
dc.date.issued2005
dc.identifier.issn1043-6618
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/595
dc.description.abstractFusidic acid and its sodium salt sodium fusidate (fusidin) are widely used antibiotics that possess immunomodulating properties. It has been shown that fusidin ameliorates the course of several organ-specific immunoinflammatory diseases and thus we investigated the effect of fusidin on myosin-induced experimental autoimmune myocarditis (EAM) in rats, a well-established animal model for human giant cell myocarditis and postmyocarditis dilated cardiomyopathy (DCM). Fusidin at doses of 80 mg kg(-1) was administrated i.m. to male Dark Agouti (DA) rats, either from days 0 to 10 (early treatment group), or from days 10 to 20 (late treatment group) after induction of EAM. Efficacy of fusidin treatment was determined on day 21 of EAM development. It was observed that both early and late treatment with fusidin markedly ameliorated clinical, histological and immunohistochemical signs of the disease. The treated rats had significantly decreased incidence of EAM, heart weight and heart weight/body weight ratio (Hw/Bw) compared with untreated animals. In contrast to the severe myocardial damage and cellular infiltration in the EAM rats, there was only focal infiltration of inflammatory cells in the myocardium of the treated rats. In both treated groups the mean microscopic score was markedly lower compared with vehicle-treated animals. In addition, the number of CD4+, ED1+ and OX6+ cells was significantly lower in myocardium of fusidin-treated rats than that in untreated group. The present findings suggest that fusidin exhibited both early and late therapeutical effect in EAM.en
dc.publisherAcademic Press Ltd- Elsevier Science Ltd, London
dc.rightsrestrictedAccess
dc.sourcePharmacological Research
dc.subjectcardiac myosinen
dc.subjectautoimmune myocarditisen
dc.subjectsodium fusidate (fusidin)en
dc.titleSuppression of experimental autoimmune myocarditis by sodium fusidate (fusidin)en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЧолић, Миодраг; Стојић-Вуканић, Зорица; Aрсеновић-Ранин, Невена; Милосављевић, П; Вучићевић, Драгана; Миленковић, М;
dc.citation.volume52
dc.citation.issue6
dc.citation.spage491
dc.citation.epage496
dc.citation.other52(6): 491-496
dc.citation.rankM22
dc.identifier.wos000233373900007
dc.identifier.doi10.1016/j.phrs.2005.08.001
dc.identifier.pmid16216521
dc.identifier.scopus2-s2.0-27644545939
dc.identifier.rcubconv_1672
dc.type.versionpublishedVersion


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