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dc.creatorBogavac-Stanojević, Nataša
dc.creatorJelić-Ivanović, Zorana
dc.creatorĐurović, Srđan
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorSpasić, Slavica
dc.creatorKalimanovska-Oštrić, Dimitra
dc.creatorMemon, Lidija
dc.date.accessioned2019-09-02T11:01:28Z
dc.date.available2019-09-02T11:01:28Z
dc.date.issued2005
dc.identifier.issn1349-2365
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/610
dc.description.abstractHigh plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-c in some studies performed mostly in hyperlipidemic subjects, but this association has not yet been investigated in CAD patients. In addition, conflicting results were obtained from in vitro studies that explored the proposed HDL effect on cytokine-induced CAM expression. The aim of the present case-control study was to investigate whether low HDL-c values are associated with CAM overexpression in normolipidemic CAD patients and healthy individuals, matched according to age and gender. Plasma HDL-c, sICAM-1, sVCAM-1, and sE-selectin were measured in 37 normolipidemic patients with angiographically verified coronary artery disease and in 52 healthy normolipidemic subjects. The sCAM values obtained in the subjects (patients or controls) with low HDL-c levels ( lt 1.03 mmol/L) were compared with the values in the subjects with high HDL-c (>= 1.03 mmol/L). No significant difference was found between sICAM-1, sVCAM-1, and E-selectin values obtained in subjects with low and high HDL-c, either among the patients or the healthy controls. In conclusion, low HDL-c levels are not associated with CAM overexpression in normolipidemic CAD patients and healthy subjects.en
dc.publisherInternational Heart Journal Association, Tokyo
dc.rightsopenAccess
dc.sourceInternational Heart Journal
dc.subjectatherosclerosisen
dc.subjecthigh-density lipoproteinsen
dc.subjectE-selectinen
dc.subjectintracellular adhesion molecule-1en
dc.subjectvascular cell adhesion molecule-1en
dc.titleLack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjectsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Спасић, С; Калимановска-Оштрић, Димитра; Мемон, Лидија; Станојевић, НБ; Ђуровић, С;
dc.citation.volume46
dc.citation.issue4
dc.citation.spage593
dc.citation.epage600
dc.citation.other46(4): 593-600
dc.citation.rankM23
dc.identifier.wos000232575300003
dc.identifier.doi10.1536/ihj.46.593
dc.identifier.pmid16157950
dc.identifier.scopus2-s2.0-33644878696
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2112/608.pdf
dc.identifier.rcubconv_1663
dc.type.versionpublishedVersion


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