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High-performance thin-layer chromatography determination of some antimycotic imidazole derivatives and preservatives in medicinal creams and a gel
dc.creator | Čakar, Mira | |
dc.creator | Popović, Gordana | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-02T11:01:29Z | |
dc.date.available | 2019-09-02T11:01:29Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 1060-3271 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/612 | |
dc.description.abstract | Simple and reliable thin-layer chromatography-densitometry methods for determination of antimycotics (bifonazole, clotrimazole, and miconazole) and preservatives (benzyl alcohol and benzoic acid) were developed. The pairs bifonazole/benzyl alcohol, clotrimazole/benzyl alcohol, and miconazole/benzoic acid were determined simultaneously. The following mobile phases were used: ethyl acetate-n-heptane-methanol-diethylamine (3 + 4.5 + 1 + 0.2, v/v/v/v) for bifonazole and benzyl alcohol; n-butyl acetate-n-heptane-methanol-dietylamine (3 + 4.5 + 1 + 0.2, v/v/v/v) for clotrimazole and benzyl alcohol; and n-butyl acetate-carbon tetrachloride-methanol-diethylamine (3 + 6 + 2.5 + 0.5, v/v/v/v) for miconazole and benzoic acid. The chromatographic zones on silica gel plates were scanned in the reflectance/absorbance mode at 230 nm (bifonazole, benzyl alcohol, miconazole, and benzoic acid) and 210 nm (clotrimazole and benzyl alcohol). The recovery for all substances ranged from 98.7 to 100.7%. The limits of detection and quantitation were 0.03 to 0.2 mu g and 0.1 to 0.5 mu g/spot, respectively. The proposed methods were applied for determination of antimycotics and preservatives in commercially available pharmaceuticals. | en |
dc.publisher | AOAC Int, Gaithersburg | |
dc.relation | Ministry for Science and Environmental Protection of Serbia, Grant #1458. | |
dc.rights | restrictedAccess | |
dc.source | Journal of AOAC International | |
dc.title | High-performance thin-layer chromatography determination of some antimycotic imidazole derivatives and preservatives in medicinal creams and a gel | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Чакар, Мира; Поповић, Гордана; Aгбаба, Даница; | |
dc.citation.volume | 88 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1544 | |
dc.citation.epage | 1548 | |
dc.citation.other | 88(5): 1544-1548 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000232578700036 | |
dc.identifier.doi | 10.1093/jaoac/88.5.1544 | |
dc.identifier.pmid | 16386007 | |
dc.identifier.scopus | 2-s2.0-27644500100 | |
dc.type.version | publishedVersion |