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dc.creatorLeposavić, Gordana
dc.creatorPejčić-Karapetrović, Branka
dc.creatorKosec, Duško
dc.date.accessioned2019-09-02T11:01:34Z
dc.date.available2019-09-02T11:01:34Z
dc.date.issued2005
dc.identifier.issn1021-7401
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/614
dc.description.abstractThe thymus structure, expression of CD4/CD8/TCR alpha beta on thymocytes and thymocyte proliferative and apoptotic indexes were analyzed in sexually immature 30-day-old and in sexually mature 60-day-old female rats neonatally androgenized (NA) by subcutaneous injection of 500 mu g testosterone propionate/day on days 1-3 and in their vehicle-administered counterparts. The treatment affected normal thymus development. Thus, at 30 days of age, there was a reduction in the thymus weight, reflecting a decrease in the main thymic compartments. However, at 60 days of age, thymus weight did not significantly differ from that in age-matched controls, since the cortical volume enlargement was followed by a proportional decrease in the medullary volume. In rats of both ages, the changes in thymic compartments most likely reflected alterations in the size of both lymphoid and nonlymphoid components. Furthermore, in NA rats, substantial changes in thymocyte phenotypic characteristics were registered, in spite of their age. In both groups of NA rats, a decrease in the relative proportion of the least mature CD4-8-TCR alpha beta- cells and in that of CD4+8- TCR alpha beta-/TCR alpha beta(low) cells followed by an increase in the percentage of their successor CD4+8+TCR alpha beta-/TCR alpha beta(low) cells was detected. In addition, in 30-day-old NA rats, the relative proportions of CD4+8+TCR alpha beta(high) cells ( just positively selected) and that of mature single positive (CD4+8- and CD4-8+) and CD4-8- double negative TCR alpha beta(high) cells, were reduced, while in 60-day-old NA rats only the percentage of CD4+8+TCR alpha beta(high) thymocytes was decreased. Thus, the study showed that the changes in the development of the hypothalamo-pituitary-gonadal axis induced by neonatal androgenization may affect the thymus development and intrathymic T-cell maturation. Copyrighten
dc.publisherKarger, Basel
dc.rightsrestrictedAccess
dc.sourceNeuroImmunoModulation
dc.subjectandrogenizationen
dc.subjectneonatesen
dc.subjectthymic structureen
dc.subjectthymocyte maturationen
dc.titleNeonatal androgenization affects the intrathymic T-cell maturation in ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКосец, Душко; Пејчић-Карапетровић, Бранка; Лепосавић, Гордана;
dc.citation.volume12
dc.citation.issue2
dc.citation.spage117
dc.citation.epage130
dc.citation.other12(2): 117-130
dc.citation.rankM23
dc.identifier.wos000227789400007
dc.identifier.doi10.1159/000083584
dc.identifier.pmid15785114
dc.identifier.scopus2-s2.0-17344368934
dc.identifier.rcubconv_1605
dc.type.versionpublishedVersion


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