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dc.creatorStojanović, J
dc.creatorMarinković, Valentina
dc.creatorVladimirov, S
dc.creatorVeličković, D.
dc.creatorSibinović, Predrag
dc.date.accessioned2019-09-02T11:01:48Z
dc.date.available2019-09-02T11:01:48Z
dc.date.issued2005
dc.identifier.issn0009-5893
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/623
dc.description.abstractA reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for separation of carvedilol and its impurities from Karvileks tablets. The best separation was achieved on a 100 mm x 4.6 mm, 5 mu m particle size, Chromolit RP 8e column. Use of acetonitrile-water, 45:55 (v/v), adjusted to pH 2.5 with formic acid, as mobile phase at a flow rate of 0.5 mL min(-1) enabled acceptable resolution of carvedilol, in large excess, from possible impurities, in a short elution time. UV detection was performed at 280 nm. Linearity, accuracy, precision, selectivity, and robustness were validated and found to be satisfactory. Overall, the proposed method was found to be highly sensitive, suitable, and accurate for quantitative determination of carvedilol and its impurities in dosage forms and in raw materials.en
dc.publisherVieweg, Wiesbaden
dc.rightsrestrictedAccess
dc.sourceChromatographia
dc.subjectcolumn liquid chromatographyen
dc.subjectcarvedilolen
dc.subjectimpurities and degradation productsen
dc.subjectpharmaceutical preparationsen
dc.titleDetermination of carvedilol and its impurities in pharmaceuticalsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаринковић, Валентина; Сибиновић, Предраг; Владимиров, С; Величковић, Д.; Стојановић, Ј;
dc.citation.volume62
dc.citation.issue9-10
dc.citation.spage539
dc.citation.epage542
dc.citation.other62(9-10): 539-542
dc.citation.rankM23
dc.identifier.wos000233470100014
dc.identifier.doi10.1365/s10337-005-0656-y
dc.identifier.scopus2-s2.0-27944471303
dc.identifier.rcubconv_1674
dc.type.versionpublishedVersion


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