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dc.creatorKosec, Duško
dc.creatorLavrnić, Dragana
dc.creatorApostolski, Slobodan
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:01:50Z
dc.date.available2019-09-02T11:01:50Z
dc.date.issued2005
dc.identifier.issn0020-7454
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/627
dc.description.abstractThis study was undertaken to investigate T-cell maturation ill hyperplastic thymi of patients suffering from myasthenia gravis (MG). For this purpose, the expression of the major differentiational molecules (CD4, CD8, and CD3/TCRalphass) and that of the regulator. v and activation molecules oil thymocytes from MG patients and control subjects were estimated by flow cytometric analysis. In the MG patients the increase in relative proportion of immature (CD4-8- TCRalphass-) and the most mature (CD4+8- TCRalphass(high) and CD4-8- TCRhigh encompassing immunoregulatory NKT) thymocytes followed by a decrease in that of CD4+8+CD3 /TCRalphass- cells was found. Furthermore, in these patients the relative proportion of CD4+HLA-DR+ and CD4+71+ cells was increased, whereas that of CD4+25+ cells was slightly, but significantly, decreased (reflecting, most likely, decreased contribution of T reg cells bearing this phenotype). Moreover. in MG thymi the percentage of CD45RA+ cells was reduced indicating changes in the selection processes. In keeping with this finding the reduced thymocyte apoptotic index and percentage of cells bearing apoptosing (CD4-8- TCRalphass(low)) phenotype were detected. In conclusion, the study demonstrates substantial changes in intrathymic differentiation of T cells in hyperplastic MG thymi and suggests alterations in selection events providing an increased escape of potentially? autoreactive T-cell clones, on one side, and all altered maturation and/or selection of immunoregulatory cells (NKT and CD4+8-25+ T reg cells) keeping these cell clones under control, on the other side.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Neuroscience
dc.subjectimmunoregulatory cellsen
dc.subjectmyasthenia gravisen
dc.subjectT-cell maturationen
dc.titleChanges in thymopoiesis in myasthenia gravisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКосец, Душко; Aпостолски, С; Лаврнић, Д; Лепосавић, Гордана;
dc.citation.volume115
dc.citation.issue2
dc.citation.spage223
dc.citation.epage243
dc.citation.other115(2): 223-243
dc.citation.rankM23
dc.identifier.wos000226305300006
dc.identifier.doi10.1080/00207450590519472
dc.identifier.pmid15764003
dc.identifier.scopus2-s2.0-11244318428
dc.identifier.rcubconv_1589
dc.type.versionpublishedVersion


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