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dc.creatorAntonijević, Biljana
dc.creatorBokonjić, Dubravko
dc.creatorStojiljković, Miloš P.
dc.creatorKilibarda, Vesna
dc.creatorMilovanović, Zoran A.
dc.creatorNedeljković, M
dc.creatorMaksimović, M
dc.date.accessioned2019-09-02T11:01:59Z
dc.date.available2019-09-02T11:01:59Z
dc.date.issued2005
dc.identifier.issn1742-7835
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/632
dc.description.abstractThe aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy-substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half-times were calculated. Trimedoxime (24 mg/kg intravenously) was injected 5 min. before 1.3 LD50 intravenously of poisons. Activities of brain, diaphragmal and erythrocyte acetylcholinesterase, as well as of plasma carboxylesterases were determined at different time intervals (10, 40 and 60 min.) after administration of the antidotes. Protective effect of trimedoxime decreased according to the following order: monocrotophos > heptenophos > dichlorvos. Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos. Surprisingly, trimedoxime did not induce reactivation of monocrotophos-inhibited acetylcholinesterase in any of the tissues tested. These organophosphorus compounds produced a significant inhibition of plasma carboxylesterase activity, while administration of trimedoxime led to regeneration of the enzyme activity. The same dose of trimedoxime assured survival of experimental animals poisoned by all three organophosphorus compounds, although the biochemical findings were quite different.en
dc.publisherWiley, Hoboken
dc.rightsopenAccess
dc.sourceBasic & Clinical Pharmacology & Toxicology
dc.titleEfficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophosen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНедељковић, М; Максимовић, М; Миловановић, Зоран A.; Килибарда, Весна; Бокоњић, Дубравко; Aнтонијевић, Биљана; Стојиљковић, Милош П.;
dc.citation.volume96
dc.citation.issue2
dc.citation.spage111
dc.citation.epage117
dc.citation.other96(2): 111-117
dc.citation.rankM23
dc.identifier.wos000226569500004
dc.identifier.doi10.1111/j.1742-7843.2005.pto960204.x
dc.identifier.pmid15679473
dc.identifier.scopus2-s2.0-14644414145
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2133/630.pdf
dc.identifier.rcubconv_1594
dc.type.versionpublishedVersion


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