Show simple item record

dc.creatorSavić, Miroslav
dc.creatorObradović, Dragan I.
dc.creatorUgrešić, Nenad
dc.creatorBokonjić, Dubravko
dc.date.accessioned2019-09-02T11:02:20Z
dc.date.available2019-09-02T11:02:20Z
dc.date.issued2005
dc.identifier.issn2090-5904
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/644
dc.description.abstractBenzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies. and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA A receptors containing the α 1 and α 5 subunits, whereas the effects on procedural memory can be mainly mediated by the α 1 subunit. The pervading involvement of the α 1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA A receptors. On the other hand, the role of α 5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states.en
dc.publisherHindawi Limited
dc.rightsopenAccess
dc.sourceNeural Plasticity
dc.subjectAcquisitionen
dc.subjectExplicit memoryen
dc.subjectProcedural memoryen
dc.subjectReceptoren
dc.titleMemory effects of benzodiazepines: Memory stages and types versus binding-site subtypesen
dc.typecontributionToPeriodical
dc.rights.licenseBY
dcterms.abstractОбрадовић, Драган И.; Бокоњић, Дубравко; Угрешић, Ненад; Савић, Мирослав;
dc.citation.volume12
dc.citation.issue4
dc.citation.spage289
dc.citation.epage298
dc.citation.other12(4): 289-298
dc.identifier.doi10.1155/NP.2005.289
dc.identifier.scopus2-s2.0-30444441132
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2144/642.pdf
dc.identifier.rcubconv_5157
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record