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Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes
dc.creator | Savić, Miroslav | |
dc.creator | Obradović, Dragan I. | |
dc.creator | Ugrešić, Nenad | |
dc.creator | Bokonjić, Dubravko | |
dc.date.accessioned | 2019-09-02T11:02:20Z | |
dc.date.available | 2019-09-02T11:02:20Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 2090-5904 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/644 | |
dc.description.abstract | Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies. and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABA A receptors containing the α 1 and α 5 subunits, whereas the effects on procedural memory can be mainly mediated by the α 1 subunit. The pervading involvement of the α 1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABA A receptors. On the other hand, the role of α 5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states. | en |
dc.publisher | Hindawi Limited | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Neural Plasticity | |
dc.subject | Acquisition | en |
dc.subject | Explicit memory | en |
dc.subject | Procedural memory | en |
dc.subject | Receptor | en |
dc.title | Memory effects of benzodiazepines: Memory stages and types versus binding-site subtypes | en |
dc.type | contributionToPeriodical | |
dc.rights.license | BY | |
dcterms.abstract | Обрадовић, Драган И.; Бокоњић, Дубравко; Угрешић, Ненад; Савић, Мирослав; | |
dc.citation.volume | 12 | |
dc.citation.issue | 4 | |
dc.citation.spage | 289 | |
dc.citation.epage | 298 | |
dc.citation.other | 12(4): 289-298 | |
dc.identifier.doi | 10.1155/NP.2005.289 | |
dc.identifier.scopus | 2-s2.0-30444441132 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/2144/642.pdf | |
dc.type.version | publishedVersion |