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dc.creatorMalenović, Anđelija
dc.creatorMedenica, Mirjana
dc.creatorIvanović, D
dc.creatorJančić, Biljana
dc.creatorMarković, S
dc.date.accessioned2019-09-02T11:02:28Z
dc.date.available2019-09-02T11:02:28Z
dc.date.issued2005
dc.identifier.issn0014-827X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/649
dc.description.abstractThe simple and rapid RP-HPLC method, for the simultaneous determination of lidocaine and cetrimonium bromide in the presence of pellet color corrigent, was developed. Separations were performed on a Beckman Ultrasphere ODS 4.6 mm x 15 cm, 5 μm particle column at 40°C. The mobile phase consisted of water phase and acetonitrile (72:28:V/V), pH value of the mobile phase was adjusted to 2.0 with 85% ortophosphoric acid. Bisacodil was used as an internal standard. The flow rate was 1 ml/min and UV detection was performed at 208 nm. The proposed RP-HPLC method was validated and all the parameters for the validation of the method are given. According to the obtained results, the developed method was found to be suitable and accurate for the determination of these drugs in commercial formulations.en
dc.publisherElsevier Masson SAS
dc.rightsrestrictedAccess
dc.sourceFarmaco
dc.subjectCetrimonium bromideen
dc.subjectLidocaineen
dc.subjectReversed-phase HPLCen
dc.subjectValidationen
dc.titleDevelopment and validation of RP-HPLC method for cetrimonium bromide and lidocaine determinationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаленовић, Aнђелија; Јанчић, Биљана; Меденица, Мирјана; Марковић, С; Ивановић, Д;
dc.citation.volume60
dc.citation.issue2
dc.citation.spage157
dc.citation.epage161
dc.citation.other60(2): 157-161
dc.identifier.doi10.1016/j.farmac.2004.11.004
dc.identifier.scopus2-s2.0-14744269868
dc.identifier.rcubconv_5160
dc.type.versionpublishedVersion


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