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dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorPešić, V.
dc.creatorRadojević, Katarina
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:03:00Z
dc.date.available2019-09-02T11:03:00Z
dc.date.issued2006
dc.identifier.issn0340-2096
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/670
dc.description.abstractIn order to provide a morphometrical description of the changes in the aged rat thymus and to relate them to apoptotic and proliferative activity of thymocytes, the thymuses from 3- and 18-month-old male Wistar rats and the percentages of bromodeoxyuridine-incorporating and apoptotic cells in cultures of thymocytes were assessed by stereological analysis and flow cytometry, respectively. In old rats the volume of lymphoepithelial thymic tissue is markedly reduced, reflecting a sharp decrease in the total number of thymocytes. A reduction in the proliferative capacity of thymocytes and increase in their susceptibility to apoptosis are, most likely, primarily responsible for a 7-fold reduction in thymic cellularity in old animals. Furthermore, only the volume of cortical compartment was affected by aging, while that of medulla, despite of reduced cellularity, was not significantly altered. The loss of functional tissue in aged thymus is compensated by a substantial increase in the volume of inter-lobular connective and adipose tissue, so the thymic weight remained unaltered in old rats. These results suggest that thymus of aged Wistar rats exhibits morphological characteristics similar to those found in aged human thymus and thus may serve as an animal model for further investigations of thymus-related changes in immunological aging.en
dc.publisherWiley, Hoboken
dc.rightsrestrictedAccess
dc.sourceJournal of Veterinary Medicine Series C: Anatomia Histologia Embryologia
dc.titleMorphometrical characteristics of age-associated changes in the thymus of old male wistar ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПешић, В.; Радојевић, Катарина; Плећаш-Соларовић, Босиљка; Лепосавић, Гордана;
dc.citation.volume35
dc.citation.issue6
dc.citation.spage380
dc.citation.epage386
dc.citation.other35(6): 380-386
dc.citation.rankM22
dc.identifier.wos000242221100006
dc.identifier.doi10.1111/j.1439-0264.2006.00698.x
dc.identifier.pmid17156091
dc.identifier.scopus2-s2.0-33751326325
dc.identifier.rcubconv_1803
dc.type.versionpublishedVersion


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