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dc.creatorVučković, Sonja M.
dc.creatorTomić, Maja
dc.creatorStepanović-Petrović, Radica
dc.creatorUgrešić, Nenad
dc.creatorProstran, Milica
dc.creatorBošković, Bogdan
dc.date.accessioned2019-09-02T11:03:01Z
dc.date.available2019-09-02T11:03:01Z
dc.date.issued2006
dc.identifier.issn0304-3959
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/672
dc.description.abstractIn this study, the effects of yohimbine (alpha(2)-adrenoceptor antagonist) and clonidine (alpha(2)-adrenoceptor agonist) on anti-hyperalgesia induced by carbamazepine and oxcarbazepine in a rat model of inflammatory pain were investigated. Carbamazepine (10-40 mg/kg; i.p.) and oxcarbazepine (40-160 mg/kg; i.p.) caused a significant dose-dependent reduction of the paw inflammatory hyperalgesia induced by concanavalin A (Con A, intraplantarly) in a paw pressure test in rats. Yohimbine (1-3 mg/kg; i.p.) significantly depressed the anti-hyperalgesic effects of carbamazepine and oxcarbazepine, in a dose- and time-dependent manner. Both drug mixtures (carbamazepine-clonidine and oxcarbazepine-clonidine) administered in fixed-dose fractions of the ED50 (1/2, 1/4 and 1/8) caused significant and dose-dependent reduction of the hyperalgesia induced by Con A. Isobolographic analysis revealed a significant synergistic (supra-additive) anti-hyperalgesic effect of both combinations tested. These results indicate that anti-hyperalgesic effects of carbamazepine and oxcarbazepine are, at least partially, mediated by activation of adrenergic alpha(2)-receptors. In addition, synergistic interaction for anti-hyperalgesia between carbamazepine and clonidine, as well as oxcarbazepine and clonidine in a model of inflammatory hyperalgesia, was demonstrated.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourcePain
dc.subjectcarbamazepineen
dc.subjectoxcarbazepineen
dc.subjectalpha(2)-adrenoceptorsen
dc.subjectpaw pressure testen
dc.subjectinflammatory hyperalgesiaen
dc.subjectsynergistic interactionen
dc.titleThe effects of alpha(2)-adrenoceptor agents on anti-hyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory painen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтепановић-Петровић, Радица; Бошковић, Богдан; Угрешић, Ненад; Вучковић, Соња М.; Томић, Маја; Простран, Милица;
dc.citation.volume125
dc.citation.issue1-2
dc.citation.spage10
dc.citation.epage19
dc.citation.other125(1-2): 10-19
dc.citation.rankaM21
dc.identifier.wos000241712600004
dc.identifier.doi10.1016/j.pain.2006.04.023
dc.identifier.pmid16777327
dc.identifier.scopus2-s2.0-33749353714
dc.identifier.rcubconv_1797
dc.type.versionpublishedVersion


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