dc.creator | Vučković, Sonja M. | |
dc.creator | Tomić, Maja | |
dc.creator | Stepanović-Petrović, Radica | |
dc.creator | Ugrešić, Nenad | |
dc.creator | Prostran, Milica | |
dc.creator | Bošković, Bogdan | |
dc.date.accessioned | 2019-09-02T11:03:01Z | |
dc.date.available | 2019-09-02T11:03:01Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0304-3959 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/672 | |
dc.description.abstract | In this study, the effects of yohimbine (alpha(2)-adrenoceptor antagonist) and clonidine (alpha(2)-adrenoceptor agonist) on anti-hyperalgesia induced by carbamazepine and oxcarbazepine in a rat model of inflammatory pain were investigated. Carbamazepine (10-40 mg/kg; i.p.) and oxcarbazepine (40-160 mg/kg; i.p.) caused a significant dose-dependent reduction of the paw inflammatory hyperalgesia induced by concanavalin A (Con A, intraplantarly) in a paw pressure test in rats. Yohimbine (1-3 mg/kg; i.p.) significantly depressed the anti-hyperalgesic effects of carbamazepine and oxcarbazepine, in a dose- and time-dependent manner. Both drug mixtures (carbamazepine-clonidine and oxcarbazepine-clonidine) administered in fixed-dose fractions of the ED50 (1/2, 1/4 and 1/8) caused significant and dose-dependent reduction of the hyperalgesia induced by Con A. Isobolographic analysis revealed a significant synergistic (supra-additive) anti-hyperalgesic effect of both combinations tested. These results indicate that anti-hyperalgesic effects of carbamazepine and oxcarbazepine are, at least partially, mediated by activation of adrenergic alpha(2)-receptors. In addition, synergistic interaction for anti-hyperalgesia between carbamazepine and clonidine, as well as oxcarbazepine and clonidine in a model of inflammatory hyperalgesia, was demonstrated. | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.rights | restrictedAccess | |
dc.source | Pain | |
dc.subject | carbamazepine | en |
dc.subject | oxcarbazepine | en |
dc.subject | alpha(2)-adrenoceptors | en |
dc.subject | paw pressure test | en |
dc.subject | inflammatory hyperalgesia | en |
dc.subject | synergistic interaction | en |
dc.title | The effects of alpha(2)-adrenoceptor agents on anti-hyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory pain | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Степановић-Петровић, Радица; Бошковић, Богдан; Угрешић, Ненад; Вучковић, Соња М.; Томић, Маја; Простран, Милица; | |
dc.citation.volume | 125 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 10 | |
dc.citation.epage | 19 | |
dc.citation.other | 125(1-2): 10-19 | |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000241712600004 | |
dc.identifier.doi | 10.1016/j.pain.2006.04.023 | |
dc.identifier.pmid | 16777327 | |
dc.identifier.scopus | 2-s2.0-33749353714 | |
dc.type.version | publishedVersion | |