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dc.creatorKovačević, Nada
dc.creatorČolić, Miodrag
dc.creatorBacković, Aleksandar
dc.creatorDošlov-Kokoruš, Zvezdana
dc.date.accessioned2019-09-02T11:03:07Z
dc.date.available2019-09-02T11:03:07Z
dc.date.issued2006
dc.identifier.issn0367-326X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/674
dc.description.abstractThe effect of the methanolic extract of root and rhizome of Epimedium alpinum (MEEA) on phenotype and functions of rat lymphocytes in vitro was studied. It has been found that MEEA at lower concentrations (0.1 mu g/ml and 1 mu g/ml) significantly enhanced proliferation of splenocytes and thymocytes triggered by concanavalin A (Con A), whereas higher concentrations of the extract (50 mu g/ ml-500 mu g/ml) were inhibitory. The stimulatory effect of MEEA on Con A-induced proliferation of splenocytes correlated with the up-regulation of interleukin-2 receptor alpha (IL-2R alpha) expression. In addition, increased production of IL-2 was observed when a blocking IL-2R alpha monoclonal antibody (mAb) was added to cell cultures. MEEA-suppressed proliferation of splenocytes was due to the inhibition of IL-2 production, the down-regulation of IL-2Ra expression and the induction of apoptosis. Cellular proliferation in the presence of inhibitory concentrations of MEEA higher than 50 mu g/ml could not be restored by the addition of exogenous IL-2.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceFitoterapia
dc.subjectEpimedium alpinumen
dc.subjectrat lymphocytesen
dc.subjectIL-2 productionen
dc.subjectIL-2R alpha expressionen
dc.subjectapoptosisen
dc.titleImmunomodulatory effects of the methanolic extract of Epimedium alpinum in vitroen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЧолић, Миодраг; Ковачевић, Нада; Бацковић, Aлександар; Дошлов-Кокоруш, Звездана;
dc.citation.volume77
dc.citation.issue7-8
dc.citation.spage561
dc.citation.epage567
dc.citation.other77(7-8): 561-567
dc.citation.rankM23
dc.identifier.wos000242945900015
dc.identifier.doi10.1016/j.fitote.2006.09.008
dc.identifier.pmid17070658
dc.identifier.scopus2-s2.0-33750945984
dc.identifier.rcubconv_1809
dc.type.versionpublishedVersion


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