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dc.creatorŽivković, Lada
dc.creatorPotparević, Biljana
dc.creatorĐejić, Ninoslav
dc.creatorBajić, Vladan
dc.date.accessioned2019-09-02T11:03:10Z
dc.date.available2019-09-02T11:03:10Z
dc.date.issued2006
dc.identifier.issn0047-6374
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/677
dc.description.abstractPremature centromere division (PCD) of the chromosome 18 was analyzed by using fluorescent in situ hybridization (FISH) on interphase peripheral blood lymphocytes isolated from six sporadic Alzheimer disease (AD) patients and six healthy elderly controls. Results of FISH analysis revealed that chromosome 18 expressed PCD in 5.18% interphase nuclei of AD patients, and in 2.59% interphase nuclei of age-matched controls (p lt 0.05). Our study also showed that hypoploidy and hyperploidy frequency for chromosome 18 exhibited a statistically significant increase in the AD group compared to the control one. The increase in spontaneous aneuploidy of chromosome 18 in AD patients which is correlated with PCD shows that deregulation of the time of centromere separation can be considered as a manifestation of chromosome instability leading to aneuploidy.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143018/RS//
dc.rightsrestrictedAccess
dc.sourceMechanisms of Ageing and Development
dc.subjectAlzheimer's diseaseen
dc.subjectpremature centromere divisionen
dc.subjectchromosome 18en
dc.subjectfluorescent in situ hybridizationen
dc.titleAnalysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes in Alzheimer disease patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЖивковић, Лада; Бајић, Владан; Ђејић, Нинослав; Потпаревић, Биљана;
dc.citation.volume127
dc.citation.issue12
dc.citation.spage892
dc.citation.epage896
dc.citation.other127(12): 892-896
dc.citation.rankM21
dc.identifier.wos000242976400003
dc.identifier.doi10.1016/j.mad.2006.09.004
dc.identifier.pmid17069875
dc.identifier.scopus2-s2.0-33750968801
dc.identifier.rcubconv_1811
dc.type.versionpublishedVersion


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