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dc.creatorSavić, Snežana
dc.creatorSavić, Miroslav
dc.creatorVesić, Sonja
dc.creatorVuleta, Gordana
dc.creatorMueller-Goymann, Christel
dc.date.accessioned2019-09-02T11:03:29Z
dc.date.available2019-09-02T11:03:29Z
dc.date.issued2006
dc.identifier.issn0378-5173
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/691
dc.description.abstractAn emerging class of natural surfactants, named alkylpolyglucosides, which can form both, the thermotropic and the lyotropic, liquid crystalline phases, were focused. The aim of the study was to integrate some physicochemical properties (characterised through the polarization and transmission electron microscopy, wide-angle X-ray diffraction, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, with the in vitro (the artificial skin constructs) and in vivo bioavailability of hydrocortisone (HQ, in comparison with a standard pharmacopoeial vehicle. The parameters measured in vivo were erythema index (an instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum hydration. A complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type was deduced for sugar surfactant-based vehicles. In dependence on surfactant/water/oil ratio, several thermodinamically variable fractions of water were predicted. Rheological profile of the vehicle appeared to influence the in vitro profile of permeation. A surplus of total amount of drug permeated in vitro from the alkylpolyglucoside-based vehicles coincided with the more pronounced increase of TEWL and less marked blanching action of HC from the selected alkylpolyglucoside-based vehicle tested in vivo, related to the pharmacopoeial one. These findings imply an enhanced delivery of HC from this vehicle and its putative penetration enhancing effect, probably dependent on specific distribution of the vehicle's inherent water.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectalkylpolyglucosidesen
dc.subjectlamellar gel phase/liquid crystalsen
dc.subjectinterlamellar wateren
dc.subjectin vitro/in vivo permeationen
dc.subjecthydrocortisoneen
dc.titleVehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавић, Мирослав; Весић, Соња; Вулета, Гордана; Савић, Снежана; Муеллер-Гоyманн, Цхристел;
dc.citation.volume320
dc.citation.issue1-2
dc.citation.spage86
dc.citation.epage95
dc.citation.other320(1-2): 86-95
dc.citation.rankM22
dc.identifier.wos000240253700013
dc.identifier.doi10.1016/j.ijpharm.2006.04.019
dc.identifier.pmid16730932
dc.identifier.scopus2-s2.0-33746465773
dc.identifier.rcubconv_1770
dc.type.versionpublishedVersion


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