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dc.creatorKotur-Stevuljević, Jelena
dc.creatorSpasić, Slavica
dc.creatorStefanović, Aleksandra
dc.creatorZeljković, Aleksandra
dc.creatorBogavac-Stanojević, Nataša
dc.creatorKalimanovska-Oštrić, Dimitra
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:03:38Z
dc.date.available2019-09-02T11:03:38Z
dc.date.issued2006
dc.identifier.issn1434-6621
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/697
dc.description.abstractBackground: Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated serum enzyme that protects lipoproteins from oxidative modifications. Polymorphisms in the gene, including PON1(Q192R), have been studied. However, inconsistencies regarding the above-mentioned polymorphism obscure its association with vascular disease. Methods: Using a two-substrate (paraoxon/diazoxon) activity method, we investigated the frequencies of PON1Q192R phenotypes in 261 middle-aged subjects: 156 patients with angiographically assessed coronary heart disease (CHD) and 105 CHD-free subjects as the control group. The PON1(192) phenotype was predicted from examination of the two-dimensional plot of hydrolysis rates of diazoxon vs. paraoxon and by using the antimode of the histogram of the ratio of diazoxonase/paraoxonase activity. Results: The PON1Q192R phenotype frequencies in 113 patients with occlusion) 50% (coronary artery disease-positive, CAD+ group) vs. control population were as follows: QQ (0.552 vs. 0.510), QR (0.382 vs. 0.408) and RR (0.066 vs. 0.082); chi(2) = 0.414, p = 0.813. We found lower paraoxonase (POase) and diazoxonase (DZOase) activities in the CAD+ patients when compared to the control population. According to logistic regression analysis, POase activity was a better predictor of coronary disease onset compared with DZOase activity measurements and PON1Q192R phenotyping. Conclusions: We conclude that enzyme activity (within a particular phenotypic group) is more important than phenotype alone in predicting susceptibility to coronary artery disease.en
dc.publisherWalter de Gruyter Gmbh, Berlin
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Chemistry and Laboratory Medicine
dc.subjectcoronary artery diseaseen
dc.subjectparaoxonase-1 (PON1) activityen
dc.subjectPON1(Q192R) phenotypeen
dc.titleParaoxonase-1 (PON1) activity, but not PON1(Q192R) phenotype, is a predictor of coronary artery disease in a middle-aged Serbian populationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБогавац-Станојевић, Наташа; Спасић, Славица; Зељковић, Aлександра; Калимановска-Оштрић, Димитра; Јелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Котур-Стевуљевић, Јелена; Стефановић, Aлександра;
dc.citation.volume44
dc.citation.issue10
dc.citation.spage1206
dc.citation.epage1213
dc.citation.other44(10): 1206-1213
dc.citation.rankM22
dc.identifier.wos000241193900007
dc.identifier.doi10.1515/CCLM.2006.216
dc.identifier.pmid17032132
dc.identifier.scopus2-s2.0-33750072918
dc.identifier.rcubconv_1793
dc.type.versionpublishedVersion


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