Potentiometric and volumetric determination of 6-mercaptopurine

Abstract

Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being determined potentiometrically with sodium hydroxide. The other two methods involve titration with chloramine-T, with potentiometric and visual end-point-detection. All methods afford accurate and reproducible results and can be used for routine assay of 6-mercaptopurine in tablets.