Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being determined potentiometrically with sodium hydroxide. The other two methods involve titration with chloramine-T, with potentiometric and visual end-point-detection. All methods afford accurate and reproducible results and can be used for routine assay of 6-mercaptopurine in tablets.
TY - JOUR
AU - Nikolić, Kosta
AU - Velašević, Ksenija
PY - 1990
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/70
AB - Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being determined potentiometrically with sodium hydroxide. The other two methods involve titration with chloramine-T, with potentiometric and visual end-point-detection. All methods afford accurate and reproducible results and can be used for routine assay of 6-mercaptopurine in tablets.
PB - Springer-Verlag
T2 - Mikrochimica Acta
T1 - Potentiometric and volumetric determination of 6-mercaptopurine
VL - 100
IS - 1-2
SP - 69
EP - 73
DO - 10.1007/BF01244500
ER -
@article{
author = "Nikolić, Kosta and Velašević, Ksenija",
year = "1990",
abstract = "Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being determined potentiometrically with sodium hydroxide. The other two methods involve titration with chloramine-T, with potentiometric and visual end-point-detection. All methods afford accurate and reproducible results and can be used for routine assay of 6-mercaptopurine in tablets.",
publisher = "Springer-Verlag",
journal = "Mikrochimica Acta",
title = "Potentiometric and volumetric determination of 6-mercaptopurine",
volume = "100",
number = "1-2",
pages = "69-73",
doi = "10.1007/BF01244500"
}
Nikolić, K.,& Velašević, K.. (1990). Potentiometric and volumetric determination of 6-mercaptopurine. in Mikrochimica Acta
Springer-Verlag., 100(1-2), 69-73.
https://doi.org/10.1007/BF01244500
Nikolić K, Velašević K. Potentiometric and volumetric determination of 6-mercaptopurine. in Mikrochimica Acta. 1990;100(1-2):69-73.
doi:10.1007/BF01244500 .
Nikolić, Kosta, Velašević, Ksenija, "Potentiometric and volumetric determination of 6-mercaptopurine" in Mikrochimica Acta, 100, no. 1-2 (1990):69-73,
https://doi.org/10.1007/BF01244500 . .
