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Solid lipid nanoparticles: Application in sunscreens

Čvrste lipidne nanočestice - primena u preparatima za zaštitu od UV zračenja

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2006
702.pdf (313.1Kb)
Authors
Milić, Jela
Savić, Snežana
Kovačević, Anđelka
Vuleta, Gordana
Article (Published version)
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Abstract
There are two different ways of action for sunscreens, physical sunscreens and molecular sunscreens. The presence of sunscreens on top of the horny layer can cause phototoxic and photoallergic reactions. The development of suitable products which prevent penetration of the sunscreen into the skin is a challenge for manufacturers of cosmetic products. It has been shown that solid lipid nanoparticles act as active carriers for sunscreens due to their paniculate character i.e. they represent physical sunscreens on their own. Incorporation of molececuiar sunscreens into SLN has a synergistic effect on the protective characteristics. Therefore, amount of molecular sunscreen could be decreased while maintaining the protection level (compared to a conventional emulsion). Oxybenzone (benzophenone-3) is lipophilic sunscreen is widely used in commercially available cosmetic formulations such as lotions, o/w emulsions and has been studied intensely in vitro and in vivo. The release rate of oxyben...zone is decreased when using SLN formulations compared to emulsions, thus more of the active remains on the surface of the skin; this effect is desired. Titanium dioxide (TiO2) fine particles are embedded with sunscreens into the skin to effectively attenuate UV-B radiation.

Za zaštitu kože od UV zračenja koriste se dva tipa UV filtera: molekulski i fizički UV filteri. Prisustvo UV filtera na površini rožnatog sloja kože može izazvati fototoksične i fotoalergijske reakcije. Razvoj odgovarajućih proizvoda koji će sprečiti penetraciju UV filtera u kožu izazov je za proizvođače kozmetičkih proizvoda. Pokazano je da čvrste lipidne nanočestice (eng. solid lipid nanopartides, SLN) same predstavljaju fizičke UV filtere i da su pogodne kao nosači za filtere zbog svog čestičnog karaktera. Inkorporiranjem molekulskih UV filtera u SLN postiže se sinergistički efekat zaštite, pa je moguće smanjiti količinu molekulskih UV filtera, a da nivo zaštite bude održan (u poređenju sa konvencionalnim emulzionim nosačima). Oksibenzon (benzofenon-3) je lipofilni molekulski UV filter koji nalazi veliku primenu u komercijalnim kozmetičkim preparatima (U/V emulzije i U/V kremovi) za koga je pokazano da se usporeno oslobađa kada se koristi u obliku preparata sa SLN, u poređenju sa em...ulzijama, tako da se u odgovarajućoj koncentraciji duže zadržava na površini kože. Fine čestice fizičkog UV filtera titan-dioksida (TiO2), inkorporirane u preparate za zaštitu od sunca, efikasno štite kožu od UV zračenja.

Keywords:
solid lipid nanoparticles / UV filters / oxybenzone (benzophenone-3) / TiO2 nanoparticles / čvrste lipidne nanočestice. UV filteri / oksibenzon (benzofenon-3) / nanočestice TiO2
Source:
Arhiv za farmaciju, 2006, 56, 2, 178-189
Publisher:
  • Savez farmaceutskih udruženja Srbije, Beograd

ISSN: 0004-1963

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_farfar_704
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/704
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Milić, Jela
AU  - Savić, Snežana
AU  - Kovačević, Anđelka
AU  - Vuleta, Gordana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/704
AB  - There are two different ways of action for sunscreens, physical sunscreens and molecular sunscreens. The presence of sunscreens on top of the horny layer can cause phototoxic and photoallergic reactions. The development of suitable products which prevent penetration of the sunscreen into the skin is a challenge for manufacturers of cosmetic products. It has been shown that solid lipid nanoparticles act as active carriers for sunscreens due to their paniculate character i.e. they represent physical sunscreens on their own. Incorporation of molececuiar sunscreens into SLN has a synergistic effect on the protective characteristics. Therefore, amount of molecular sunscreen could be decreased while maintaining the protection level (compared to a conventional emulsion). Oxybenzone (benzophenone-3) is lipophilic sunscreen is widely used in commercially available cosmetic formulations such as lotions, o/w emulsions and has been studied intensely in vitro and in vivo. The release rate of oxybenzone is decreased when using SLN formulations compared to emulsions, thus more of the active remains on the surface of the skin; this effect is desired. Titanium dioxide (TiO2) fine particles are embedded with sunscreens into the skin to effectively attenuate UV-B radiation.
AB  - Za zaštitu kože od UV zračenja koriste se dva tipa UV filtera: molekulski i fizički UV filteri. Prisustvo UV filtera na površini rožnatog sloja kože može izazvati fototoksične i fotoalergijske reakcije. Razvoj odgovarajućih proizvoda koji će sprečiti penetraciju UV filtera u kožu izazov je za proizvođače kozmetičkih proizvoda. Pokazano je da čvrste lipidne nanočestice (eng. solid lipid nanopartides, SLN) same predstavljaju fizičke UV filtere i da su pogodne kao nosači za filtere zbog svog čestičnog karaktera. Inkorporiranjem molekulskih UV filtera u SLN postiže se sinergistički efekat zaštite, pa je moguće smanjiti količinu molekulskih UV filtera, a da nivo zaštite bude održan (u poređenju sa konvencionalnim emulzionim nosačima). Oksibenzon (benzofenon-3) je lipofilni molekulski UV filter koji nalazi veliku primenu u komercijalnim kozmetičkim preparatima (U/V emulzije i U/V kremovi) za koga je pokazano da se usporeno oslobađa kada se koristi u obliku preparata sa SLN, u poređenju sa emulzijama, tako da se u odgovarajućoj koncentraciji duže zadržava na površini kože. Fine čestice fizičkog UV filtera titan-dioksida (TiO2), inkorporirane u preparate za zaštitu od sunca, efikasno štite kožu od UV zračenja.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Solid lipid nanoparticles: Application in sunscreens
T1  - Čvrste lipidne nanočestice - primena u preparatima za zaštitu od UV zračenja
VL  - 56
IS  - 2
SP  - 178
EP  - 189
UR  - https://hdl.handle.net/21.15107/rcub_farfar_704
ER  - 
@article{
author = "Milić, Jela and Savić, Snežana and Kovačević, Anđelka and Vuleta, Gordana",
year = "2006",
abstract = "There are two different ways of action for sunscreens, physical sunscreens and molecular sunscreens. The presence of sunscreens on top of the horny layer can cause phototoxic and photoallergic reactions. The development of suitable products which prevent penetration of the sunscreen into the skin is a challenge for manufacturers of cosmetic products. It has been shown that solid lipid nanoparticles act as active carriers for sunscreens due to their paniculate character i.e. they represent physical sunscreens on their own. Incorporation of molececuiar sunscreens into SLN has a synergistic effect on the protective characteristics. Therefore, amount of molecular sunscreen could be decreased while maintaining the protection level (compared to a conventional emulsion). Oxybenzone (benzophenone-3) is lipophilic sunscreen is widely used in commercially available cosmetic formulations such as lotions, o/w emulsions and has been studied intensely in vitro and in vivo. The release rate of oxybenzone is decreased when using SLN formulations compared to emulsions, thus more of the active remains on the surface of the skin; this effect is desired. Titanium dioxide (TiO2) fine particles are embedded with sunscreens into the skin to effectively attenuate UV-B radiation., Za zaštitu kože od UV zračenja koriste se dva tipa UV filtera: molekulski i fizički UV filteri. Prisustvo UV filtera na površini rožnatog sloja kože može izazvati fototoksične i fotoalergijske reakcije. Razvoj odgovarajućih proizvoda koji će sprečiti penetraciju UV filtera u kožu izazov je za proizvođače kozmetičkih proizvoda. Pokazano je da čvrste lipidne nanočestice (eng. solid lipid nanopartides, SLN) same predstavljaju fizičke UV filtere i da su pogodne kao nosači za filtere zbog svog čestičnog karaktera. Inkorporiranjem molekulskih UV filtera u SLN postiže se sinergistički efekat zaštite, pa je moguće smanjiti količinu molekulskih UV filtera, a da nivo zaštite bude održan (u poređenju sa konvencionalnim emulzionim nosačima). Oksibenzon (benzofenon-3) je lipofilni molekulski UV filter koji nalazi veliku primenu u komercijalnim kozmetičkim preparatima (U/V emulzije i U/V kremovi) za koga je pokazano da se usporeno oslobađa kada se koristi u obliku preparata sa SLN, u poređenju sa emulzijama, tako da se u odgovarajućoj koncentraciji duže zadržava na površini kože. Fine čestice fizičkog UV filtera titan-dioksida (TiO2), inkorporirane u preparate za zaštitu od sunca, efikasno štite kožu od UV zračenja.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Solid lipid nanoparticles: Application in sunscreens, Čvrste lipidne nanočestice - primena u preparatima za zaštitu od UV zračenja",
volume = "56",
number = "2",
pages = "178-189",
url = "https://hdl.handle.net/21.15107/rcub_farfar_704"
}
Milić, J., Savić, S., Kovačević, A.,& Vuleta, G.. (2006). Solid lipid nanoparticles: Application in sunscreens. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(2), 178-189.
https://hdl.handle.net/21.15107/rcub_farfar_704
Milić J, Savić S, Kovačević A, Vuleta G. Solid lipid nanoparticles: Application in sunscreens. in Arhiv za farmaciju. 2006;56(2):178-189.
https://hdl.handle.net/21.15107/rcub_farfar_704 .
Milić, Jela, Savić, Snežana, Kovačević, Anđelka, Vuleta, Gordana, "Solid lipid nanoparticles: Application in sunscreens" in Arhiv za farmaciju, 56, no. 2 (2006):178-189,
https://hdl.handle.net/21.15107/rcub_farfar_704 .

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