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dc.creatorTopić, Aleksandra
dc.creatorJelić-Ivanović, Zorana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorSpasić, Slavica M.
dc.date.accessioned2019-09-02T11:03:51Z
dc.date.available2019-09-02T11:03:51Z
dc.date.issued2006
dc.identifier.issn0188-4409
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/705
dc.description.abstractBackground. Alpha-1 antitrypsin (AAT) is an important serine protease inhibitor in human plasma. Its major physiological role is to inhibit neutrophil elastase (NE) in the lower respiratory tract and protect lung tissue from destruction. Recent studies indicated an etiological role of NE in lung cancer development. The aim of this study was to investigate the association of alpha-1 antitrypsin deficiency (AATD) with lung cancer in patients with four different histological types of cancer: squamous cell carcinoma, adenocarcinomas, large cell carcinoma and small cell carcinoma. Methods. Phenotyping was carried out by isoelectric focusing (pH 4.2-4.9). We compared the frequency of AATD phenotypes in 186 lung cancer patients with the value obtained in our previous study in a healthy Serbian population (3.7%) using the Fisher exact test. Results. Allele frequencies in patients were Pi*M 0.9677, Pi*Z 0.0215, Pi*S 0.0081 and Pi*other rare 0.0027. Eleven of the 186 lung cancer patients (5.9%) were AATD heterozygotes with moderate deficiencies (PiMZ and PiMS). When this value was compared with AATD heterozygote frequency obtained in the healthy individuals (3.7%), the difference was close to the level of significance (p = 0.055). However, individuals with AATD phenotypes had a higher risk of developing squamous cell lung cancer then those with non-deficient AAT variants (OR = 4.51, 95% CI = 1.66-12.29). Conclusions. Our findings provide evidence of an association between AAT phenotypes with moderate deficiency and squamous cell lung cancer.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceArchives of Medical Research
dc.subjectserine protease inhibitorsen
dc.subjectalpha-1 antitrypsin deficiencyen
dc.subjectlung canceren
dc.subjectneutrophil elastaseen
dc.titleAssociation of moderate alpha-1 antitrypsin deficiency with lung cancer in the Serbian populationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Спасић, Славица М.; Топић, Aлександра С.;
dc.citation.volume37
dc.citation.issue7
dc.citation.spage866
dc.citation.epage870
dc.citation.other37(7): 866-870
dc.citation.rankM23
dc.identifier.wos000240894300010
dc.identifier.doi10.1016/j.arcmed.2006.05.006
dc.identifier.pmid16971227
dc.identifier.scopus2-s2.0-33748794783
dc.identifier.rcubconv_1786
dc.type.versionpublishedVersion


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