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dc.creatorČudina, Olivera
dc.creatorJanković, Ivana
dc.creatorComor, Mirjana
dc.creatorVladimirov, Sote
dc.date.accessioned2019-09-02T11:04:02Z
dc.date.available2019-09-02T11:04:02Z
dc.date.issued2006
dc.identifier.issn0021-9797
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/712
dc.description.abstractIn this study, the interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. The strong dependence of the partition coefficient K-x on QUIN concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (2.3 +/- 0.4) x 10(3) mol(-1) dm(3) was obtained. QUIN-CTAB binding constant was also calculated from micellar liquid chromatography (MLC) and this method was found to be not accurate enough for its determination.en
dc.publisherAcademic Press Inc Elsevier Science, San Diego
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142066/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142072/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Colloid and Interface Science
dc.subjectquinapril anionen
dc.subjectCTABen
dc.subjectmicellesen
dc.subjectbinding constanten
dc.subjectpartition coefficienten
dc.subjectMLCen
dc.titleInteraction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈанковић, Ивана; Чудина, Оливера; Цомор, Мирјана; Владимиров, Соте;
dc.citation.volume301
dc.citation.issue2
dc.citation.spage692
dc.citation.epage696
dc.citation.other301(2): 692-696
dc.citation.rankM22
dc.identifier.wos000239937700047
dc.identifier.doi10.1016/j.jcis.2006.05.025
dc.identifier.pmid16765977
dc.identifier.scopus2-s2.0-33746926406
dc.identifier.rcubconv_1767
dc.type.versionpublishedVersion


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