Study of protolytic equilibria of flurazepam
Само за регистроване кориснике
1990
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Protolytic equilibria of flurazepam, a diprotic base which is sparingly soluble in water, were investigated. The investigations were carried out in the pH range 0-12, at constant ionic strength (0.1 M NaCl) and 25 ± 0.1 °C, by the application of spectrophotometric, pH-metric and solubility methods. The acidity, hydrolysis and equilibrium constants in the heterogeneous system were determined. In addition, a method, based on the application of a formation function to the hydrolytic process, is proposed. Finally, buffer characteristics of flurazepam in the homogeneous and heterogeneous systems were studied.
Кључне речи:
Flurazepam / Heterogeneous equilibria / Hydrolysis / Protolytic equilibria / Two-phase bufferИзвор:
The Analyst, 1990, 115, 11, 1457-1462Институција/група
PharmacyTY - JOUR AU - Pfendt, Lidija AU - Janjić, T.J AU - Popović, Gordana PY - 1990 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/75 AB - Protolytic equilibria of flurazepam, a diprotic base which is sparingly soluble in water, were investigated. The investigations were carried out in the pH range 0-12, at constant ionic strength (0.1 M NaCl) and 25 ± 0.1 °C, by the application of spectrophotometric, pH-metric and solubility methods. The acidity, hydrolysis and equilibrium constants in the heterogeneous system were determined. In addition, a method, based on the application of a formation function to the hydrolytic process, is proposed. Finally, buffer characteristics of flurazepam in the homogeneous and heterogeneous systems were studied. T2 - The Analyst T1 - Study of protolytic equilibria of flurazepam VL - 115 IS - 11 SP - 1457 EP - 1462 DO - 10.1039/an9901501457 ER -
@article{ author = "Pfendt, Lidija and Janjić, T.J and Popović, Gordana", year = "1990", abstract = "Protolytic equilibria of flurazepam, a diprotic base which is sparingly soluble in water, were investigated. The investigations were carried out in the pH range 0-12, at constant ionic strength (0.1 M NaCl) and 25 ± 0.1 °C, by the application of spectrophotometric, pH-metric and solubility methods. The acidity, hydrolysis and equilibrium constants in the heterogeneous system were determined. In addition, a method, based on the application of a formation function to the hydrolytic process, is proposed. Finally, buffer characteristics of flurazepam in the homogeneous and heterogeneous systems were studied.", journal = "The Analyst", title = "Study of protolytic equilibria of flurazepam", volume = "115", number = "11", pages = "1457-1462", doi = "10.1039/an9901501457" }
Pfendt, L., Janjić, T.J,& Popović, G.. (1990). Study of protolytic equilibria of flurazepam. in The Analyst, 115(11), 1457-1462. https://doi.org/10.1039/an9901501457
Pfendt L, Janjić T, Popović G. Study of protolytic equilibria of flurazepam. in The Analyst. 1990;115(11):1457-1462. doi:10.1039/an9901501457 .
Pfendt, Lidija, Janjić, T.J, Popović, Gordana, "Study of protolytic equilibria of flurazepam" in The Analyst, 115, no. 11 (1990):1457-1462, https://doi.org/10.1039/an9901501457 . .