Study of protolytic equilibria of flurazepam

dc.creator	Pfendt, Lidija
dc.creator	Janjić, T.J
dc.creator	Popović, Gordana
dc.date.accessioned	2019-09-02T10:47:51Z
dc.date.available	2019-09-02T10:47:51Z
dc.date.issued	1990
dc.identifier.issn	0003-2654
dc.identifier.uri	https://farfar.pharmacy.bg.ac.rs/handle/123456789/75
dc.description.abstract	Protolytic equilibria of flurazepam, a diprotic base which is sparingly soluble in water, were investigated. The investigations were carried out in the pH range 0-12, at constant ionic strength (0.1 M NaCl) and 25 ± 0.1 °C, by the application of spectrophotometric, pH-metric and solubility methods. The acidity, hydrolysis and equilibrium constants in the heterogeneous system were determined. In addition, a method, based on the application of a formation function to the hydrolytic process, is proposed. Finally, buffer characteristics of flurazepam in the homogeneous and heterogeneous systems were studied.	en
dc.rights	restrictedAccess
dc.source	The Analyst
dc.subject	Flurazepam	en
dc.subject	Heterogeneous equilibria	en
dc.subject	Hydrolysis	en
dc.subject	Protolytic equilibria	en
dc.subject	Two-phase buffer	en
dc.title	Study of protolytic equilibria of flurazepam	en
dc.type	article
dc.rights.license	ARR
dcterms.abstract	Пфендт, Лидија; Јањић, Т.Ј; Поповић, Гордана;
dc.citation.volume	115
dc.citation.issue	11
dc.citation.spage	1457
dc.citation.epage	1462
dc.citation.other	115(11): 1457-1462
dc.identifier.doi	10.1039/an9901501457
dc.identifier.scopus	2-s2.0-0024998112
dc.type.version	publishedVersion