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dc.creatorStefanović, D
dc.creatorAntonijević, Biljana
dc.creatorBokonjić, Dubravko
dc.creatorStojiljković, Miloš P.
dc.creatorMilovanović, Zoran A.
dc.creatorNedeljković, M
dc.date.accessioned2019-09-02T11:05:36Z
dc.date.available2019-09-02T11:05:36Z
dc.date.issued2006
dc.identifier.issn1742-7835
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/773
dc.description.abstractThe development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The present study was undertaken to evaluate the ability of sodium bicarbonate to improve protective effects of standard antidotes in rats poisoned with dichlorvos. The aim of this experiment was to establish the correlation between protective effects and biochemical parameters relevant for acid-base status. In order to examine the protective effect of both standard antidotes and their combinations, groups of experimental animals were poisoned subcutaneously with increasing doses of dichlorvos. Immediately thereafter, rats were treated with atropine 10 mg/kg intramuscularly, oximes 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally. These antidotes were administered either as single doses or in combinations. In the biochemical part of the experiments, rats were poisoned with dichlorvos 1.3 LD50 (10.64 mg/kg) subcutaneously and immediately thereafter treated with atropine 10 mg/kg intramuscularly, oximes (trimedoxime or obidoxime) 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally either as single doses or in combinations. Parameters relevant for acid-base status were measured 10 minutes after the administration of antidotes. The results of our study indicate that addition of sodium bicarbonate to standard antidotes significantly improves protective effects of atropine, obidoxime and trimedoxime. Correlation between protection and biochemical outcome is clearly evident when sodium bicarbonate is being added to atropine.en
dc.publisherWiley, Hoboken
dc.rightsopenAccess
dc.sourceBasic & Clinical Pharmacology & Toxicology
dc.titleEffect of sodium bicarbonate in rats acutely poisoned with dichlorvosen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојиљковић, Милош П.; Недељковић, М; Aнтонијевић, Биљана; Бокоњић, Дубравко; Миловановић, Зоран A.; Стефановић, Д;
dc.citation.volume98
dc.citation.issue2
dc.citation.spage173
dc.citation.epage180
dc.citation.other98(2): 173-180
dc.citation.rankM22
dc.identifier.wos000235017700009
dc.identifier.doi10.1111/j.1742-7843.2006.pto_68.x
dc.identifier.pmid16445591
dc.identifier.scopus2-s2.0-33645053014
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2192/771.pdf
dc.identifier.rcubconv_1453
dc.type.versionpublishedVersion


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