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Development and validation of liquid chromatography method for the separation of valdecoxib and its SC-77852 impurity

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2006
Authors
Zečević, Mira
Savić, G
Živanović, L
Article (Published version)
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Abstract
A reversed-phase liquid chromatography method has been developed for the separation of valdecoxib and impurity SC-77852. The best results were achieved using a mobile phase-methanol: 1% water solution TEA (52 : 48 v/v), pH 7.35 (adjusted with 85% orthophosphoric acid), column temperature 24 degrees C. Separation was carried out on XTerra (TM) RP18 (150mm x 4,6 mm), particle size 5 mu m, flow rate 1ml/min, using detection on 220 nm. The method was statistically validated for its selectivity, linearity, precision (repeatability), and robustness. Quantitation and detection limits were determined for both valdecoxib and SC-77852. Method robustness was further evaluated by performing full factorial design experiment. Validated method was used for assay of valdecoxib and SC-77852 in Bextra (R) film-coated tablets.
Keywords:
valdecoxib / robustness / experimental design / RP HPLC / SC-77852
Source:
Analytical Letters, 2006, 39, 9, 1875-1890
Publisher:
  • Taylor & Francis Inc, Philadelphia
Projects:
  • Sinteza, kvantitativni odnosi između strukture/osobina i aktivnosti, fizičko-hemijska karakterizacija i analiza farmakološki aktivnih supstanci (RS-142071)

DOI: 10.1080/00032710600721605

ISSN: 0003-2719

WoS: 000238565900009

Scopus: 2-s2.0-33745626824
[ Google Scholar ]
6
6
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/775
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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