dc.creator | Zečević, Mira | |
dc.creator | Savić, G | |
dc.creator | Živanović, L | |
dc.date.accessioned | 2019-09-02T11:05:38Z | |
dc.date.available | 2019-09-02T11:05:38Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0003-2719 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/775 | |
dc.description.abstract | A reversed-phase liquid chromatography method has been developed for the separation of valdecoxib and impurity SC-77852. The best results were achieved using a mobile phase-methanol: 1% water solution TEA (52 : 48 v/v), pH 7.35 (adjusted with 85% orthophosphoric acid), column temperature 24 degrees C. Separation was carried out on XTerra (TM) RP18 (150mm x 4,6 mm), particle size 5 mu m, flow rate 1ml/min, using detection on 220 nm. The method was statistically validated for its selectivity, linearity, precision (repeatability), and robustness. Quantitation and detection limits were determined for both valdecoxib and SC-77852. Method robustness was further evaluated by performing full factorial design experiment. Validated method was used for assay of valdecoxib and SC-77852 in Bextra (R) film-coated tablets. | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS// | |
dc.rights | restrictedAccess | |
dc.source | Analytical Letters | |
dc.subject | valdecoxib | en |
dc.subject | robustness | en |
dc.subject | experimental design | en |
dc.subject | RP HPLC | en |
dc.subject | SC-77852 | en |
dc.title | Development and validation of liquid chromatography method for the separation of valdecoxib and its SC-77852 impurity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Живановић, Л; Савић, Г; Зечевић, Мира; | |
dc.citation.volume | 39 | |
dc.citation.issue | 9 | |
dc.citation.spage | 1875 | |
dc.citation.epage | 1890 | |
dc.citation.other | 39(9): 1875-1890 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000238565900009 | |
dc.identifier.doi | 10.1080/00032710600721605 | |
dc.identifier.scopus | 2-s2.0-33745626824 | |
dc.type.version | publishedVersion | |