Приказ основних података о документу

dc.creatorŽivanović, Lj.
dc.creatorZigić, G.
dc.creatorZečević, Mira
dc.date.accessioned2019-09-02T11:06:47Z
dc.date.available2019-09-02T11:06:47Z
dc.date.issued2006
dc.identifier.issn0021-9673
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/814
dc.description.abstractA sensitive, precise, and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous determination of fluoroquinolone antibacterial ofloxacin and its degradation products: decarboxy ofloxacin, 9-piperazino ofloxacin, des-methyl ofloxacin, and ofloxacin-N-oxide. The proposed RP-HPLC method allowed separation of all five compounds simultaneously with the total time of the analysis not more than 15 min. The relative standard deviation (RSD) values for quantification of DOF, POF, MOF, OF, and NOF were of 0.77, 0.58, 0.51, 0.10, and 0.70%, respectively, indicating a good precision of the method. The limits of detection for DOF, POF, MOF, OF, and NOF were 0.10, 0.13, 0.06, 0.03, and 0.03 mu g mL(-1), respectively. The described method can be used for simultaneous identification and quantification of all analysed compounds in different pharmaceutical formulations.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography A
dc.subjectliquid chromatographyen
dc.subjectofloxacinen
dc.subjectdegradation productsen
dc.subjectdeterminationen
dc.titleInvestigation of chromatographic conditions for the separation of ofloxacin and its degradation productsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗигић, Г.; Живановић, Љ.; Зечевић, Мира;
dc.citation.volume1119
dc.citation.issue1-2
dc.citation.spage224
dc.citation.epage230
dc.citation.other1119(1-2): 224-230
dc.citation.rankaM21
dc.identifier.wos000238707100031
dc.identifier.doi10.1016/j.chroma.2006.02.029
dc.identifier.pmid16551467
dc.identifier.scopus2-s2.0-33744792287
dc.type.versionpublishedVersion


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Приказ основних података о документу