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dc.creatorLeposavić, Gordana
dc.creatorPešić, Vesna
dc.creatorKosec, Duško
dc.creatorRadojević, Katarina
dc.creatorArsenović-Ranin, Nevena
dc.creatorPilipović, Ivan
dc.creatorPerišić, Milica
dc.creatorPlećaš-Solarović, Bosiljka
dc.date.accessioned2019-09-02T11:06:48Z
dc.date.available2019-09-02T11:06:48Z
dc.date.issued2006
dc.identifier.issn0531-5565
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/816
dc.description.abstractTo elucidate the effects of ageing on T-cell-maturation, in 3- and 18-month-old rats, we analysed the expression of: (i) CD4/CD8/TCR alpha beta and (ii) Thy-1, which is supposed to be a regulator of TCR alpha beta signalling, and thereby the thymocyte selection thresholds. Since an essential role for TCR alpha beta signalling in the development of CD4+25+T-reg-cells was suggested, the frequency of these cells was also quantified. We demonstrated that, as for mice, early thymocyte differentiational steps within the CD4-8- double negative (DN) developmental stage are age-sensitive. Furthermore, we revealed that TCRao-dependent stages of T-cell development are affected by ageing, most likely due to an impaired expression of Thy-1 on TCR alpha beta(low) thymocytes entering selection processes. The diminished frequency of the post-selection CD4+8+ double positive (DP) cells in aged rats, together with an overrepresentation of mature single positive (SP) cells, most probably suggests more efficient differentiational transition from the DP TCR alpha beta(high) to the SP TCR alpha beta(high) developmental stage, which is followed by an increase in pre-migration proliferation of the mature SP cells. Moreover, the study indicated impaired intrathymic generation of CD4+25+T-reg-cells in aged rats, thus providing a possible explanation for the increased frequency of autoimmune diseases in ageing.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceExperimental Gerontology
dc.subjectageingen
dc.subjectT-cell differentiationen
dc.subjectCD90 expressionen
dc.subjectthymocyte apoptosisen
dc.subjectConAen
dc.subjectCD4+25+thymocytesen
dc.titleAge-associated changes in CD90 expression on thymocytes and in TCR-dependent stages of thymocyte maturation in male ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПеришић, Милица; Плећаш-Соларовић, Босиљка; Aрсеновић-Ранин, Невена; Радојевић, Катарина; Косец, Душко; Пешић, Весна; Лепосавић, Гордана; Пилиповић, Иван;
dc.citation.volume41
dc.citation.issue6
dc.citation.spage574
dc.citation.epage589
dc.citation.other41(6): 574-589
dc.citation.rankM21
dc.identifier.wos000238899600006
dc.identifier.doi10.1016/j.exger.2006.03.006
dc.identifier.pmid16632291
dc.identifier.scopus2-s2.0-33745000082
dc.identifier.rcubconv_1729
dc.type.versionpublishedVersion


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