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dc.creatorSavić, Miroslav
dc.creatorObradović, Dragan I.
dc.creatorUgrešić, Nenad
dc.creatorCook, James M.
dc.creatorYin, Wenyuan
dc.creatorvan Linn, Michael
dc.creatorBokonjić, Dubravko
dc.date.accessioned2019-09-02T11:07:08Z
dc.date.available2019-09-02T11:07:08Z
dc.date.issued2006
dc.identifier.issn0091-3057
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/828
dc.description.abstractBenzodiazepine site inverse agonists may increase or decrease locomotor activity in rodents, depending on the experimental settings. We have compared the behavioral responses to environmental novelty of rats treated with the non-selective inverse agonist DMCM (2 mg/kg) and the alpha(1)-subunit affinity-selective inverse agonist 3-EBC (15 mg/kg). The behavior in spontaneous locomotor assay (during 45 min) and elevated plus maze (EPM) was automatically recorded. In the EPM, general activity-related parameters were similarly decreased, whereas only DMCM inhibited open-arm activity. In the locomotor assay, both compounds depressed locomotion in the first 15 min and activity in the central zone of the chamber. However, the influence of 3-EBC was less pronounced. The alpha(1)-subunit selective antagonist beta-CCt (15 mg/kg) attenuated locomotor depression, but not the central-zone avoidance elicited by DMCM. When habituated to the chamber, DMCM-treated animals emitted a plateau phase of activity, which disappeared by adding beta-CCt. Hence, inhibition of activity in exposed areas may be mediated by non-alpha(1)-subunits, whereas both alpha(1) and non-alpha(1)-subunits may participate in suppression of activity in more protective areas of an apparatus. Hyperlocomotion in habituated animals may depend primarily on the alpha(1)-subunit. Moreover, the bimodal influence of inverse agonists on locomotion can be biphasic, observable in the same experiment.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationPHS HHS - 46851
dc.rightsrestrictedAccess
dc.sourcePharmacology Biochemistry and Behavior
dc.subjectanxietyen
dc.subjectexplorationen
dc.subjectbeta-carbolinesen
dc.subjectGABA(A1) receptoren
dc.subjectelevated plus mazeen
dc.subjectspontaneous locomotor activityen
dc.titleBenzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influenceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавић, Мирослав; Цоок, Јамес М.; ван Линн, Мицхаел; Угрешић, Ненад; Обрадовић, Драган И.; Yин, Wенyуан; Бокоњић, Дубравко;
dc.citation.volume84
dc.citation.issue1
dc.citation.spage35
dc.citation.epage42
dc.citation.other84(1): 35-42
dc.citation.rankM22
dc.identifier.wos000239223400006
dc.identifier.doi10.1016/j.pbb.2006.04.001
dc.identifier.pmid16725185
dc.identifier.scopus2-s2.0-33745655022
dc.identifier.rcubconv_1744
dc.type.versionpublishedVersion


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